Evidence map›Paper›PMID 40334519›Full record

ReviewCurrent opinion in structural biology2025

Structural and biochemical studies of mobile retrotransposon proteins in action.

Akanksha Thawani, Kathleen Collins, Eva Nogales

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in structural biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Akanksha ThawaniCalifornia Institute for Quantitative Biosciences (QB3), Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA. Electronic address: athawani@berkeley.edu.
Kathleen CollinsCalifornia Institute for Quantitative Biosciences (QB3), Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA. Electronic address: kcollins@berkeley.edu.
Eva NogalesCalifornia Institute for Quantitative Biosciences (QB3), Berkeley, CA, USA; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA; Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA. Electronic address: enogales@lbl.gov.

Funding

Human genetic supplementation without donor DNA or a DNA breakDP1HL156819 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI COLLINS, KATHLEEN · 2020 to 2024
$5.8M
NHLBI NIH HHS DP1 HL156819
6 · The paper itself

Abstract

Autonomous non-long-terminal repeat (non-LTR) retrotransposons, including long interspersed elements (LINEs), are mobile genetic elements abundant in eukaryotic species that shape the genomic landscape and host physiology in both health and disease. Non-LTR retrotransposons create new genomic copies through a mechanism termed target-primed reverse transcription, where the retrotransposon-encoded protein nicks target DNA to prime reverse transcription templated by bound RNA, typically its own encoding mRNA. Until recently, structural information on non-LTR retrotransposons was lacking due to challenges in purification and reconstitution of active complexes. Recent biochemical studies and cryo-electron microscopy structures of complexes from insect, bird, and turtle site-specific R2 retrotransposons and the human LINE-1 retrotransposon have provided important insights. Here we discuss these studies and their implications for retrotransposon evolution and eukaryotic genome biology.

Indexed as

RetroelementsAnimalsHumansLong Interspersed Nucleotide ElementsRetroelements

Identifiers

PMID40334519
PMCPMC12503042

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.