Evidence map›Paper›PMID 40335479›Full record

ArticleTranslational psychiatry2025

Transcriptional evidence of reduced BDNF trophic capacity in the post-mortem human midbrain of schizophrenia cases with high inflammation.

Jessica J Chandra, Yunting Zhu, Alice Petty, Yasmine Kostoglou, William X Haynes, Maree J Webster, Cynthia S Weickert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. The role ofEpigenetics · 2026
    Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica J ChandraSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia.ORCID http://orcid.org/0009-0000-5363-3037
Yunting ZhuDepartment of Neuroscience & Physiology, Upstate Medical University, Syracuse, NY, 13210, USA.ORCID http://orcid.org/0000-0002-2072-209X
Alice PettySchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia.ORCID http://orcid.org/0000-0001-7058-4185
Yasmine KostoglouSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia.ORCID http://orcid.org/0009-0005-8128-5902
William X HaynesSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia.ORCID http://orcid.org/0009-0001-1413-0119
Maree J WebsterLaboratory of Brain Research, Stanley Medical Research Institute, Rockville, MD, 20850, USA.ORCID http://orcid.org/0000-0002-8778-4148
Cynthia S WeickertSchizophrenia Research Laboratory, Neuroscience Research Australia, Randwick, NSW, 2031, Australia. c.weickert@neura.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated inflammation in the midbrain of ~45% of people with schizophrenia may relate to altered trophic support for neurons. Dopamine neurons require trophic support from Brain-Derived Neurotrophic Factor (BDNF), that signals via the full-length Tropomyosin kinase B receptor (TrkB

Indexed as

Brain-Derived Neurotrophic FactorInflammationMesencephalonNeuroinflammatory DiseasesSchizophreniaAdultAgedAnimalsAntipsychotic AgentsDopaminergic NeuronsFemaleHumansMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsAntipsychotic AgentsBDNF protein, humanBrain-Derived Neurotrophic FactorMembrane GlycoproteinsNerve Tissue ProteinsNGFR protein, humanNR4A2 protein, humanNuclear Receptor Subfamily 4, Group A, Member 2Receptors, Nerve Growth FactorReceptor, trkBRNA, Messengertropomyosin-related kinase-B, human

Identifiers

PMID40335479
PMCPMC12059047

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.