SynthesisEuropean journal of clinical nutrition2025
Mediterranean diet and rheumatoid arthritis: A nine-year cohort study and systematic review with meta-analysis.
Synthesis in European journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Molecular mechanisms and risk factors in rheumatoid arthritis: a comprehensive review.Inflammopharmacology · 2026Pooled it
- The Impact of Oral-Gut Microbiota Structure and Its Manipulation on RA Development and Management.Food science & nutrition · 2026Review
- Adjunctive Mediterranean Diet in a Middle-Aged Male With Autoimmune Encephalitis and Generalized Tonic-Clonic Seizures: A Longitudinal Case Report.Clinical case reports · 2026Article
- Review
- Degree of Food Processing and the Risk of Immune-Mediated Inflammatory Diseases: A Prospective Analysis of the SUN Cohort.Nutrients · 2026Article
- Geroscience insights into difficult-to-treat rheumatoid arthritis: the role of unhealthy aging, comorbidity, and therapeutic complexity.GeroScience · 2026Review
- The Oral-Gut-Immune-Nutrition Axis in Rheumatoid Arthritis: Molecular Mechanisms and Therapeutic Implications.International journal of molecular sciences · 2026Review
- Pain and Nutrition in Dementia and Alzheimer's Phase 1: a cross-sectional, observational study design.Frontiers in dementia · 2026Article
- The Role of Nutrition in the Development, Management, and Prevention of Rheumatoid Arthritis: A Comprehensive Review.Nutrients · 2025Review
- Mediterranean diet, metabolic signature, genetic predisposition, and risk of rheumatoid arthritis: a large-scale population-based prospective cohort study.The American journal of clinical nutrition · 2025Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the Mediterranean diet (MD) has beneficial effects on heart health, cognitive function, cancer, and other chronic diseases, little is known about its effect on rheumatoid arthritis (RA). This study aimed to examine the association between adherence to MD and the risk of developing rheumatoid arthritis RA.
methodsWe conducted a cohort study and a systematic review. A total of 117,341 RA-free participants from the UK Biobank were included in 2006-2010 and followed for incident RA until 2021. The MEDI-LITE score was calculated using the consumption of nine food components to estimate adherence to MD. We examined the associations between the MEDI-LITE score and the risk of RA using the Cox proportional hazard model. Relevant studies for the systematic review were identified through six databases. We performed a meta-analysis to pool the effect estimates from our cohort study and identified relevant studies.
resultsDuring a median follow-up of 9.42 years, 773 participants developed RA. Compared with the bottom quartile of the MEDI-LITE score, the risk of RA was lower in the highest quartile (adjusted hazard ratio (HR) = 0.713, 95% CI = 0.580 to 0.876). Six studies were included in the meta-analysis. The pooled odds ratio (OR) for the highest versus lowest adherence to MD and the risk of RA was 0.838 (95% CI = 0.758 to 0.926).
conclusionHigher adherence to MD was associated with a lower risk of RA. Our finding provides updated evidence on the importance of diet in RA development and novel directions for RA prevention.
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