Evidence map›Paper›PMID 40335773›Full record

ArticleNature neuroscience2025

Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster.

Maheva Andriatsilavo, Carolina Barata, Eric Reifenstein, Alexandre Dumoulin, Tian Tao Griffin, Suchetana Bias Dutta, Esther T Stoeckli, Max von Kleist, P Robin Hiesinger, Bassem A Hassan

Abstract read
PubMed Publisher
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Imprecision in Vision: Lessons From Neural Circuits in the Fly.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Vertebrate and Invertebrate Animal Models for the Study of Down Syndrome.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Maheva AndriatsilavoInstitut du Cerveau-Paris Brain Institute (ICM), Sorbonne Université, Inserm, CNRS, Hôpital Pitié-Salpêtrière, Paris, France.ORCID http://orcid.org/0000-0002-4479-1911
Carolina BarataDepartment of Mathematics and Computer Science, Free University, Berlin, Germany.ORCID http://orcid.org/0000-0003-0187-8635
Eric ReifensteinDepartment of Mathematics and Computer Science, Free University, Berlin, Germany.
Alexandre DumoulinDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-2420-6877
Tian Tao GriffinInstitut du Cerveau-Paris Brain Institute (ICM), Sorbonne Université, Inserm, CNRS, Hôpital Pitié-Salpêtrière, Paris, France.
Suchetana Bias DuttaInstitut du Cerveau-Paris Brain Institute (ICM), Sorbonne Université, Inserm, CNRS, Hôpital Pitié-Salpêtrière, Paris, France.
Esther T StoeckliDepartment of Molecular Life Sciences, University of Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-8485-0648
Max von KleistDepartment of Mathematics and Computer Science, Free University, Berlin, Germany.ORCID http://orcid.org/0000-0001-6587-6394
P Robin HiesingerDivision of Neurobiology of the Institute for Biology, Free University, Berlin, Germany.ORCID http://orcid.org/0000-0003-4698-3527
Bassem A HassanInstitut du Cerveau-Paris Brain Institute (ICM), Sorbonne Université, Inserm, CNRS, Hôpital Pitié-Salpêtrière, Paris, France. bassem.hassan@icm-institute.org.ORCID http://orcid.org/0000-0001-9533-4908

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-10-IAIHU-06Deutsche Forschungsgemeinschaft (German Research Foundation) 450430223Deutsche Forschungsgemeinschaft (German Research Foundation) Research Unit 5289 RobustCircuitDeutsche Forschungsgemeinschaft (German Research Foundation) Research Unit 5289 RobustCircuit project P2Deutsche Forschungsgemeinschaft (German Research Foundation) Research Unit 5289 RobustCircuit project Z1Deutsche Forschungsgemeinschaft (German Research Foundation) Research Unit Syntophagy RP7Fondation Roger de Spoelberch (Roger de Spoelberch Foundation) Roger De Spoelberch PrizeSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (Swiss National Science Foundation) 310030_185247U.S. Department of Health & Human Services | NIH | Office of Extramural Research, National Institutes of Health (OER) 1R01NS121874-01
6 · The paper itself

Abstract

Variation in brain wiring contributes to non-heritable behavioral individuality. How and when these individualized wiring patterns emerge and stabilize during development remains unexplored. In this study, we investigated the axon targeting dynamics of Drosophila visual projecting neurons called DCNs/LC14s, using four-dimensional live-imaging, mathematical modeling and experimental validation. We found that alternative axon targeting choices are driven by a sequence of two independent genetically encoded stochastic processes. Early Notch lateral inhibition segregates DCNs into Notch

Indexed as

AxonsVisual PathwaysAnimalsAnimals, Genetically ModifiedDrosophila melanogasterDrosophila ProteinsModels, NeurologicalDrosophila Proteins

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.