Evidence mapPaperPMID 40336254Full record

ArticleGut microbes2025

Distinct gut microbiota and metabolome features of tissue-specific insulin resistance in overweight and obesity.

Kelly M Jardon, Alexander Umanets, Anouk Gijbels, Inez Trouwborst, Gabby B Hul, Els Siebelink, Lars M M Vliex, Jacco J A J Bastings, Rosa Argamasilla, Elodie Chenal and 4 more

Abstract read
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. A Synbiotic of Lacto-Nutrients · 2026
    Article
  3. [Research progress on the effects of maternal gut microbiota in gestational obesity on offspring and potential mechanisms].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026
    Review
  4. Review
  5. Review
  6. Gut Microbiota-Mediated Mechanisms of Traditional Chinese Medicine in Obesity Management.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026
    Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kelly M JardonTiFN, Wageningen, The Netherlands.ORCID 0000-0001-8859-375X
Alexander UmanetsCentre for Healthy Eating & Food Innovation, Maastricht University Campus Venlo, Venlo, The Netherlands.ORCID 0000-0001-8139-0925
Anouk GijbelsTiFN, Wageningen, The Netherlands.ORCID 0000-0002-1128-5481
Inez TrouwborstTiFN, Wageningen, The Netherlands.ORCID 0000-0001-9538-7954
Gabby B HulTiFN, Wageningen, The Netherlands.ORCID 0000-0002-6763-4265
Els SiebelinkDivision of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.ORCID 0000-0001-7986-575X
Lars M M VliexDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0002-5295-4223
Jacco J A J BastingsDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0003-4363-8955
Rosa ArgamasillaDSM-Firmenich, Kaiseraugst, Switzerland.ORCID 0000-0002-0251-9581
Elodie ChenalDSM-Firmenich, Kaiseraugst, Switzerland.
Koen VenemaCentre for Healthy Eating & Food Innovation, Maastricht University Campus Venlo, Venlo, The Netherlands.ORCID 0000-0001-7046-5127
Lydia A AfmanTiFN, Wageningen, The Netherlands.ORCID 0000-0002-7939-6217
Gijs H GoossensDepartment of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center+, Maastricht, The Netherlands.ORCID 0000-0002-2092-3019
Ellen E BlaakTiFN, Wageningen, The Netherlands.ORCID 0000-0002-2496-3464

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin resistance (IR) is an early marker of cardiometabolic deterioration which may develop heterogeneously in key metabolic organs, including the liver (LIR) and skeletal muscle (MIR). This tissue-specific IR is characterized by distinct metabolic signatures, but the role of the gut microbiota in its etiology remains unclear. Here, we profiled the gut microbiota, its metabolites and the plasma metabolome in individuals with either a LIR or MIR phenotype (

Indexed as

BacteriaGastrointestinal MicrobiomeInsulin ResistanceMetabolomeObesityOverweightAdultFatty Acids, VolatileFecesFemaleGlucagon-Like Peptide 1HumansLiverMaleMiddle AgedMuscle, SkeletalFatty Acids, VolatileGlucagon-Like Peptide 1GLP-1gut metabolitesgut microbiotametabolic subtypingprecision healthTissue-specific insulin resistance: obesity

Identifiers

PMID40336254
PMCPMC12064058

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.