Evidence map›Paper›PMID 40336272›Full record

Trial reportEthnicity & health2025

Addressing the knowledge and recruitment gap in Alzheimer's disease and precision medicine research among Native people: an innovative randomized controlled trial.

Luciana E Hebert, Cara Kulbacki-Fabisiak, Clemma Muller, Amanda Boyd, Marcia O'Leary, Erin Poole, Madison Ramos, Daniel Barker, Ka'imi Sinclair, Spero M Manson and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Ethnicity & health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Luciana E HebertInstitute for Research and Education to Advance Community Health (IREACH), Washington State University, Spokane, WA, USA.
Cara Kulbacki-FabisiakInstitute for Research and Education to Advance Community Health (IREACH), Washington State University, Spokane, WA, USA.
Clemma MullerInstitute for Research and Education to Advance Community Health (IREACH), Washington State University, Spokane, WA, USA.
Amanda BoydInstitute for Research and Education to Advance Community Health (IREACH), Washington State University, Spokane, WA, USA.
Marcia O'LearyMissouri Breaks Industries Research, Inc., Eagle Butte, SD, USA.
Erin PooleCenters for American Indian and Alaska Native Health, University of Colorado Denver, Denver, CO, USA.
Madison RamosInstitute for Research and Education to Advance Community Health (IREACH), Washington State University, Spokane, WA, USA.
Daniel BarkerInstitute for Research and Education to Advance Community Health (IREACH), Washington State University, Spokane, WA, USA.
Ka'imi SinclairInstitute for Research and Education to Advance Community Health (IREACH), Washington State University, Spokane, WA, USA.
Spero M MansonCenters for American Indian and Alaska Native Health, University of Colorado Denver, Denver, CO, USA.
Dedra BuchwaldUniversity of Washington, Seattle, WA, USA.

Funding

University of Washington Alzheimer's Disease Research CenterP30AG066509 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$4.6M
Advancing Alzheimer's Disease Communication and Recruitment Science among American Indians and Alaska NativesK01AG066063 · WASHINGTON STATE UNIVERSITY · 2025 to 2025
$87k
NIA NIH HHS K01 AG066063NIA NIH HHS P30 AG066509NIMHD NIH HHS U54 MD000507
6 · The paper itself

Abstract

backgroundThe American Indian and Alaska Native (AI/AN) population is increasing and AI/AN people are living longer than ever before. Although aging-related health issues such as cognitive impairment, dementia, and Alzheimer's disease (AD) are becoming more visible among this population, reliable data on AD prevalence and risk factors among AI/AN people are nearly nonexistent. Concurrently, precision medicine (PM) has demonstrated significant potential for detecting and treating diseases such as AD. For PM to promote health equity for underserved populations, it must not exacerbate existing health disparities and bias in research. There is also little information about preferences among AI/AN people for communicating information regarding AD, PM, or recruitment into clinical trials. Communication barriers and few known facilitators contribute to low rates of AI/AN research participation. This study seeks to address the gaps in AD and PM research among AI/AN communities and promote knowledge of, attitudes towards, and interest and participation in AD-related PM research efforts.

methodsWe designed a three-armed RCT to determine the effect of a culturally tailored brochure and video compared to non-tailored recruitment materials. Participants were recruited in Rapid City, South Dakota and were required to meet the following eligibility criteria: 1) identify as AI/AN; 2) be able to speak, read, and understand English; 3) be aged 40 or older; and 4) have the cognitive and decisional capacity to consent and sign and date the informed consent document.

resultsWe enrolled 914 in the RCT and 812 have been randomized to a study condition. The mean age is 54 years (standard deviation = 10.3 years); 62% are female. Overall, 22% reported a parent, grandparent or sibling have been diagnosed with AD, and 22% reported a family member with an other type of dementia. One quarter (25%) of participants reported having an undiagnosed memory problem themselves, and 22% reported having a family member with undiagnosed memory problems. Of randomized participants, 743 (72%) enrolled in the research registry.

conclusionsThis study will inform future recruitment efforts for ADRD-focused clinical trials. Enrollment of AI/AN participants in an Alzheimer's Disease-Precision Medicine (AD-PM) Registry will provide opportunity for future research on this topic in partnership with this population.

Indexed as

Alzheimer DiseaseAmerican Indian or Alaska NativeHealth Knowledge, Attitudes, PracticePatient SelectionPrecision MedicineAgedFemaleHumansMaleMiddle AgedAlaska NativeAlzheimer's DiseaseAmerican IndianGood health and well-beingPartnerships for the goalsPrecision MedicinerecruitmentReduced inequalitiesregistry

Identifiers

PMID40336272
PMCPMC12126279

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.