ReviewPhilosophical transactions. Series A, Mathematical, physical, and engineering sciences2025
Computational modelling of biological systems now and then: revisiting tools and visions from the beginning of the century.
Review in Philosophical transactions. Series A, Mathematical, physical, and engineering sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Models of the human heart for biomedical research: Opportunities and challenges.Physiological reports · 2026Review
- Evaluation of Cerebral Blood Flow and Cerebral Autoregulation Using Synthetic Data and In Silico Modeling.CNS neuroscience & therapeutics · 2026Article
- Review
- Weaving the Digital Tapestry: Methods for Emulating Cohorts of Cardiac Digital Twins Using Gaussian Processes.Annals of biomedical engineering · 2026Article
- Models of cardiomyocyte-non-myocyte electrical interactions.The Journal of physiology · 2026Review
- Understanding Cancer Health Disparities.Cancers · 2026Review
- AI-powered in silico twins: redefining precision medicine through simulation, personalization, and predictive healthcare.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2025Review
- Micropatterning and Nanodropletting of Titanium by Shifted Surface Laser Texturing Significantly Enhances In Vitro Osteogenesis of Healthy and Osteoporotic Mesenchymal Stromal Cells.Journal of functional biomaterials · 2025Article
- Precision cardiac electrophysiology: toward digital twins and beyond.Journal of precision medicine (Amsterdam, Netherlands) · 2025Article
- In Silico Research Is Rewriting the Rules of Drug Development: Is It the End of Human Trials?Cureus · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Since the turn of the millennium, computational modelling of biological systems has evolved remarkably and sees matured use spanning basic and clinical research. While the topic of the peri-millennial debate about the virtues and limitations of 'reductionism and integrationism' seems less controversial today, a new apparent dichotomy dominates discussions: mechanistic versus data-driven modelling. In light of this distinction, we provide an overview of recent achievements and new challenges with a focus on the cardiovascular system. Attention has shifted from generating a universal model of
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.