ArticleDementia and geriatric cognitive disorders extra
Transcranial Magnetic Stimulation Induces White Matter Microstructure Alterations in Patients with Mild Cognitive Impairment.
Article in Dementia and geriatric cognitive disorders extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of transcranial magnetic stimulation for mild cognitive impairment: a systematic review and meta-analysis of randomized controlled trials.Frontiers in neurologyPooled it
- The Potential of Rehabilitation to Amplify Experience-Induced Myelin Plasticity and Remyelination in Multiple Sclerosis: A Narrative Review.Current neurology and neuroscience reports · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The aim of this study was to investigate whether exposure to noninvasive brain stimulation with high-frequency repetitive transcranial magnetic stimulation (rTMS) applied over the left dorsolateral prefrontal cortex (DLPFC) can improve memory and regulate white matter (WM) microstructure. Methods: Twenty-two mild cognitive impairment participants who were randomly assigned to the real and the sham groups received 10 sessions and sham-controlled 10 Hz rTMS over the DLPFC. All patients underwent cognitive assessments and diffusion tensor imaging scans before and after the intervention. Brain regions that showed significant differences in fractional anisotropy (FA) values were selected as the regions of interest to calculate the correlation with cognitive scores. Results: In the real group, FA values in the left middle frontal gyrus and bilateral parahippocampal gyrus increased and in the right superior frontal gyrus decreased. No significant FA change was detected in the sham group. Furthermore, the FA value of the left middle frontal gyrus was positively correlated with Boston Naming Test (BNT) scores. The change of FA value in the right superior frontal gyrus was positively correlated with the change in the Trail Making Test (TMT-B) score. Conclusions: This study provides new evidence for rTMS to regulate the abnormal WM microstructure in some special regions and causally ameliorate cognitive performance in MCI, which may be the underlying neural mechanism of intervention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.