ArticleKidney diseases (Basel, Switzerland)
Repeated Kidney Biopsy in Membranoproliferative Glomerulonephritis.
Article in Kidney diseases (Basel, Switzerland). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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8 authors.
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Abstract
Introduction: Membranoproliferative glomerulonephritis (MPGN) is a heterogeneous pattern of glomerular injury. Repeated kidney biopsies may elucidate pathogenic mechanisms and guide diagnostic strategies. Methods: We included 82 patients diagnosed with MPGN by kidney biopsy who underwent at least two biopsies between 1997 and 2023 at Peking University First Hospital. Clinical and pathological data were analyzed retrospectively. Results: Of 342 MPGN patients, 95 (28%) had repeated biopsies (0.9-4.0 years apart). This incidence was higher than in other glomerulonephropathies under immunosuppression. Among the 82 patients analyzed (excluding kidney transplants and ≤3-month biopsy intervals), 42 were initially diagnosed with non-MPGN pathology. At the second biopsy, proteinuria increased (from 2.9 to 6.3 g/day), eGFR declined (from 76 to 47 mL/min/1.73 m Conclusion: In this study, about half and one-third of patients underwent morphological and etiological reclassification, respectively. Stronger complement deposition may drive morphological changes. Repeated kidney biopsies are crucial for diagnosing MGRS, especially in patients with negative immunofixation.
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