ArticleTranslational gastroenterology and hepatology2025
Topics and trends in gastroesophageal reflux disease research over the past 60 years: a text mining and network analysis.
Article in Translational gastroenterology and hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Can bile salts affect the contractile oesophageal activity associated with gastroesophageal reflux disease?World journal of gastroenterology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Gastroesophageal reflux disease (GERD) presents a complex pathophysiological challenge with intricate interactions among its biological components, yet the mechanisms remain incompletely understood. This study aimed to conduct a quantitative analysis to investigate the concentration and evolution of domain knowledge in GERD research. Methods: A bibliographic search in PubMed retrieved 18,459 abstracts of experimental studies on GERD, published between 1963 and 2022. Abstracts were scanned automatically for 477 biological components proposed in recent publications, which are represented by a set of (I) genes and molecules (n=180), (II) definition of cytology, histology, and anatomy (n=54), (III) clinical definition (n=243). For each component, semantic synonyms were recovered from catalogues and domain knowledge. The results are visualized as networks indicating the frequency at which different components are referenced together within each abstract. Results: Over time the GERD network has seen a progression in the increasing of new components and connectivity. The clinical definition appears to be the most abundant, while studies exploring micro-level mechanisms remain notably scarce. Meanwhile, certain pivotal components consistently attract significant attention, forming crucial elements in this multifactorial disease. However, the micro-level analysis reveals a recent plateau in progress, indicating a bottleneck phase currently. Conclusions: GERD domain knowledge has remained confined within established frameworks over history, highlighting the importance of developing novel integrated research paradigms among endless data to bridge the gap between bench and bedside.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.