ArticleCurrent drug discovery technologies2025
Article in Current drug discovery technologies, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundCardiovascular disease continues to be a major global health challenge, characterized by high rates of mortality and morbidity. Medicinal plants, rich in bioactive compounds, offer potential avenues for reducing the incidence of cardiovascular disease.
objectiveThe objective of this research was to evaluate the efficacy of Thymus atlanticus (T. atlanticus) aqueous extract in preventing hyperlipidemia induced by a
methodsMale Wistar rats were divided into three groups (n=5). The first group (normal control group) received a normal basal diet. The second group (HFSD group) received a HFSD containing a normal diet (68.5%), fat (15%), cholesterol (1.5%), and sucrose (15%). The third group (HFSD treated with thyme extract) received the HFSD and was administered orally with
resultsThe results showed that HFSD intake elevated plasmatic lipids, blood fasting glucose, hepatic biochemical parameters, and inflammation. Moreover, HFSD resulted in increased liver weight, hepatic lipids, and oxidative stress. However, the treatment with T. atlanticus extract attenuated the altered parameters by lowering or restoring the levels of plasmatic lipids (TGs: -12.21 %; LDL-C: - 21.49 %), glycated hemoglobin (-23.33 %), hepatic parameters (AST: -25.04 %; ALT: -10.42%; ALP: -42.81%), and inflammation. Additionally, thyme extract reduced the levels of hepatic lipids (TGs: -21.13 %; TC: -12.77 %) and ameliorated hepatic oxidative status by reducing malondialdehyde levels (-10.87 %) and enhancing the antioxidant effect (+25.71 %) of hepatic extract.
conclusionWe conclude that the traditionally used aqueous extract of
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