Evidence map›Paper›PMID 40338090›Full record

ArticlemSphere2025

Antibiofilm properties of 4-hydroxy-3-methyl-2-alkenylquinoline, a novel

McKinley D Williams, Taylor R Sweeney, Sabrina Trieu, Ravi Orugunty, Abdelahhad Barbour, Fereshteh Younesi, Michael Glogauer, Nopakorn Hansanant, Ronald Shin, Shi-En Lu and 6 more

Abstract read
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

McKinley D WilliamsDepartment of Biology, Texas A&M University, College Station, Texas, USA.ORCID 0000-0002-8494-2315
Taylor R SweeneyDepartment of Biology, Texas A&M University, College Station, Texas, USA.
Sabrina TrieuDepartment of Biology, Texas A&M University, College Station, Texas, USA.
Ravi OruguntyAntimicrobial Division, Sano Chemicals Inc., Bryan, Texas, USA.
Abdelahhad BarbourFaculty of Dentistry, University of Toronto, Toronto, Canada.ORCID 0000-0003-0184-8890
Fereshteh YounesiFaculty of Dentistry, University of Toronto, Toronto, Canada.
Michael GlogauerFaculty of Dentistry, University of Toronto, Toronto, Canada.
Nopakorn HansanantDepartment of Biology, Texas A&M University, College Station, Texas, USA.
Ronald ShinCentral Alabama High-Field NMR Facility, Structural Biology Shared Facility, Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Shi-En LuDepartment of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi State, MIssissippi, USA.
Kevin CaoAntimicrobial Division, Sano Chemicals Inc., Bryan, Texas, USA.
Abraham TenorioAntimicrobial Division, Sano Chemicals Inc., Bryan, Texas, USA.
Sigmund J HaidacherDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Anthony M HaagDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Thomas D HorvathDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, Texas, USA.
Leif SmithDepartment of Biology, Texas A&M University, College Station, Texas, USA.ORCID 0000-0002-0876-7260

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
Preclinical Development of OCF001 for Treatment of Yeast InfectionsR42AI131792 · NIAID · SANO CHEMICALS, INC · PI SMITH, JAMES LEIF · 2019 to 2021
$2.9M
800 MHz NMR Spectrometer for the Central Alabama High-Field NMR FacilityS10RR022994 · NCRR · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KRISHNA, NEPALLI RAMA · 2009 to 2009
$2.0M
Lead Compound Discovery from Engineered Analogs of OccidiofunginR41AI131792 · NIAID · SANO CHEMICALS, INC · PI SMITH, JAMES LEIF · 2017 to 2017
$225k
National Institute of Allergy and Infectious Diseases 2R42AI131792National Institute of Allergy and Infectious Diseases R42AI131792NCI NIH HHS P30 CA013148NCRR NIH HHS S10 RR022994NIAID NIH HHS R41 AI131792NIAID NIH HHS R42 AI131792
6 · The paper itself

Abstract

Biofilms are an important colonization mechanism employed by several microbial species to better establish themselves and monopolize the acquisition of resources across different environs. Some bacteria have evolved specialized metabolites that, when secreted, disrupt the formation and stability of biofilms generated by competing heterospecies, providing the producing organism with an ecological advantage. Soil-derived species are probable candidates for the identification of such compounds, given the intense level of competition that occurs within the terrestrial ecosystem. The MS14 strain of

Indexed as

AlkaloidsAnti-Bacterial AgentsBiofilmsBurkholderiaQuinolinesMississippiSoil MicrobiologyAlkaloidsAnti-Bacterial AgentsQuinolinesantibacterialantimicrobial resistancebiofilmBurkholderiametabolitequinolone

Identifiers

PMID40338090
PMCPMC12108052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.