ArticleNeurochemical research2025
Developmental and Neuroprotective Effects of α-Terpineol in MPTP-Induced Parkinsonism in Zebrafish Larvae.
Article in Neurochemical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Astrocytic and microglial cell functions in neuroinflammatory diseases and their animal models.Frontiers in cellular neuroscience · 2025Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Parkinson's disease (PD) is caused by dopaminergic neurodegeneration and α-synuclein aggregation. The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), used to replicate PD symptoms, disrupts erythropoiesis, leading to anemia, potentially contributing to dopaminergic neurotoxin-induced developmental toxicity and further investigation into novel therapeutic approaches for reversing PD pathology is strongly advocated. The monoterpene α-terpineol (α-TPN) exhibits several pharmacological effects, including neuroprotection. This study aims to investigate the developmental and neuroprotective roles of α-TPN in a PD model of zebrafish embryos induced by MPTP. Our findings suggest that α-TPN significantly guards early developmental processes, as evidenced by improved survival rates, enhanced hatching rates, stabilized heart rate and amelioration of phenotypic abnormalities. In addition, α-TPN shows strong neuroprotective effects by enhancing locomotor function and improving acetylcholinesterase (AChE) activity in MPTP larvae. Moreover, α-TPN markedly reduces oxidative stress by lowering intracellular reactive oxygen species (ROS), lipid accumulation and apoptotic signatures. Collectively our findings highlight the dual role of α-TPN in promoting healthy development and protecting MPTP toxicity, emphasizing its potential as a therapeutic candidate for PD and related neurodegenerative disorders.
Indexed as
Identifiers
40338397What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.