Evidence mapPaperPMID 40338653Full record

ReviewPain management2025

Pharmacological and non-pharmacological approaches to temporomandibular disorder chronic pain: a narrative review.

Fanny Jogna, Adriana Graenicher A, Quentin Rey-Millet, Alexandra Groz, Jehanne De Grasset, Fabiola Stollar, Matteo Coen, Anna Faivre

Abstract readReview
In one paragraph

Review in Pain management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Management strategies for burning mouth syndrome: a comprehensive review.Journal of oral & facial pain and headache · 2026
    Review
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fanny JognaDivision of General Internal Medicine, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Adriana Graenicher ADivision of General Internal Medicine, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Quentin Rey-MilletDivision of Anesthesiology, Department of Acute Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Alexandra GrozHealth Care Directorate, Geneva University Hospital, University Hospitals of Geneva, Geneva, Switzerland.
Jehanne De GrassetMultidisciplinary Center of Integrative Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Fabiola StollarMultidisciplinary Center of Integrative Medicine, University Hospitals of Geneva, Geneva, Switzerland.
Matteo CoenDivision of General Internal Medicine, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland.ORCID 0000-0002-6156-1691
Anna FaivreDivision of General Internal Medicine, Department of Medicine, University Hospitals of Geneva, Geneva, Switzerland.ORCID 0000-0002-1752-7533

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporomandibular disorders (TMD) involve the temporomandibular joint and related structures, causing chronic pain, impaired jaw function, and reduced quality of life. TMD has multifactorial origins, including mechanical, neuromuscular, and inflammatory factors. Chronic TMD pain is difficult to manage due to its complex pathophysiology and the limited long-term effectiveness of existing treatments. A combination of pharmacological and non-pharmacological strategies is essential for optimal pain management. This narrative review provides an integrative overview of current treatments for TMD-associated chronic pain. Pharmacological options discussed include analgesics, muscle relaxants, antidepressants, anticonvulsants, and botulinum toxin injections. Non-pharmacological strategies include physical therapy, cognitive-behavioral therapy, acupuncture, and lifestyle modifications. A comprehensive literature search was conducted using PubMed, Embase.com, Cochrane, and Evidence Alerts databases through October 2024. We focused on original research articles, randomized controlled trials, narrative and systematic reviews, and meta-analyses. Effective management of chronic TMD pain requires a multidisciplinary approach tailored to individual needs. Evidence supports the integration of physical and psychological therapies into treatment plans. Future research should aim to develop targeted interventions that address underlying mechanisms of TMD pain and evaluate the long-term outcomes of noninvasive therapies.

Indexed as

Chronic PainPain ManagementTemporomandibular Joint DisordersCognitive Behavioral TherapyHumanschronic paincomplementary therapyintegrative medicinenociceptive painpain managementpharmacologyTemporomandibular disorders

Identifiers

PMID40338653
PMCPMC12118397

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.