Trial reportThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Association Between Changes in Body Composition and Physical Function After Intensive Behavioral Weight-loss Intervention: A Look AHEAD Trial Subgroup Analysis.
Trial report in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
9 authors.
Kacey ChaeDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0009-0008-2785-2947
Amie F BettencourtDepartment of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Denise K HoustonSection on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Eleanor M SimonsickTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.ORCID 0000-0002-5460-3494
Luigi FerrucciTranslational Gerontology Branch, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.ORCID 0000-0002-6273-1613
Rita R KalyaniDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1530-6884
Nancy SchoenbornDivision of Geriatric Medicine and Gerontology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Jeanne M ClarkDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Kimberly A GudzuneDivision of General Internal Medicine, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Funding
Look AHEAD: Action for Health in DiabetesU01DK057136 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW, WAGENKNECHT, LYNNE E · 1999 to 2020
$54.9M
SHOW PROJECTU01DK057154 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NATHAN, DAVID M · 1999 to 2020
$23.1M
Look AHEAD: Action for Health DiabetesU01DK057178 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 1999 to 2020
$21.2M
The Look AHEAD Continuation: Action for Health in DiabetesU01DK057078 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI JOHNSON, KAREN C · 1999 to 2020
$20.1M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057135 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI WADDEN, THOMAS A. · 1999 to 2020
$20.0M
The Look AHEAD Continuation: Action for Health in DiabetesU01DK056992 · NIDDK · MIRIAM HOSPITAL · PI WING, RENA R · 1999 to 2020
$20.0M
Look AHEAD: Action for Health in Diabetes ContinuationU01DK057151 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CATENACCI, VICTORIA A · 1999 to 2020
$19.4M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW) TRIALU01DK057177 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FOREYT, JOHN P. · 1999 to 2020
$18.0M
Study of Health Outcomes of Weight Loss (Look AHEAD)U01DK057182 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JEFFERY, ROBERT W · 1999 to 2020
$17.9M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057002 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JAKICIC, JOHN M · 1999 to 2020
$17.9M
STUDY OF HEALTH OUTCOMES OF WEIGHT-LOSS (SHOW)U01DK057149 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI CLARK, JEANNE M · 1999 to 2020
$17.4M
STUDY OF HEALTH OUTCOMES OF WEIGHT LOSSU01DK056990 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GREENWAY, FRANK · 1999 to 2020
backgroundIntentional weight loss improves physical function among older adults with obesity, despite the associated lean mass loss. However, prior studies have not assessed the impacts of weight loss on physical function and body composition among older adults with type 2 diabetes mellitus and obesity, a population at high risk for sarcopenia and functional decline. Our objective was to examine differences in body composition changes by physical function status among middle-aged and older adults with type 2 diabetes mellitus and overweight/obesity participating in an intensive weight-loss intervention of diet and exercise over 12 months.
methodsWe conducted a secondary analysis of 12-month data from the Look AHEAD dual-energy X-ray absorptiometry substudy among participants randomized to intervention (n = 603). Independent variables included dual-energy X-ray absorptiometry-derived percent change in appendicular lean mass and fat mass. The dependent variable was SF-36 physical function subscale change categorized as worsened (decrease ≥ 5), stable (change ± 4), or improved (increase ≥ 5). We examined the associations using ANOVA.
resultsOverall, participants had a mean age of 58.3 (SD 6.7) and 63% were women-8% had worsened, 69% stable, and 22% improved physical function. Differences in mean percent appendicular lean mass change between physical function groups were nonsignificant (worsened -3.7%; stable -4.8%; improved -5.6%; p = .05). Mean percent fat mass change was significantly different across physical function groups (worsened -9.3%; stable -14.6%; improved -17.9%; p < .01).
conclusionsLean mass loss associated with lifestyle weight-loss intervention does not negatively affect physical function, rather the intervention appears to improve physical function by reducing adiposity among adults with type 2 diabetes mellitus and overweight/obesity.
Indexed as
Body CompositionDiabetes Mellitus, Type 2ObesityWeight LossWeight Reduction ProgramsAbsorptiometry, PhotonAgedExerciseFemaleHumansMaleMiddle AgedOverweightSecondary Data AnalysisBody compositionCaloric restrictionDiabetesFunctional performanceObesity
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.