Evidence map›Paper›PMID 40340398›Full record

ArticleJournal of virology2025

Dexamethasone disrupts intracellular pH homeostasis to delay coronavirus infectious bronchitis virus cell entry via sodium hydrogen exchanger 3 activation.

Jun Dai, Yiyi Feng, Hong Long, Ying Liao, Lei Tan, Yingjie Sun, Cuiping Song, Xusheng Qiu, Chan Ding

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Virus infection and vesicle trafficking.Frontiers in immunology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun DaiShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.ORCID 0000-0001-7914-3802
Yiyi FengShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
Hong LongExperimental Animal Center, Zunyi Medical University, Zunyi, China.
Ying LiaoShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
Lei TanShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.ORCID 0000-0002-5362-1359
Yingjie SunShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.ORCID 0000-0002-6086-5722
Cuiping SongShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.
Xusheng QiuShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.ORCID 0000-0001-6961-9774
Chan DingShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China.ORCID 0000-0003-0216-2129

Funding

National Natural Science Foundation of China 32272978Natural Science Foundation of Shanghai Municipality 21ZR1476800Qian Ke Ping Tai Project NO. [2021]1350-028Shanghai Agriculture Applied Technology Development Promgram 2022-02-08-00-12-F01154Zunyi Science and Technology Project NO. [2023]192
6 · The paper itself

Abstract

Coronavirus entry into host cells enables the virus to initiate its replication cycle efficiently while evading host immune response. Cell entry is intricately associated with pH levels in the cytoplasm or endosomes. In this study, we observed that the sodium hydrogen exchanger 3 (Na

Indexed as

Antiviral AgentsDexamethasoneInfectious bronchitis virusSodium-Hydrogen Exchanger 3Virus InternalizationAnimalsCell LineChlorocebus aethiopsCoronavirus InfectionsEndosomesHomeostasisHumansHydrogen-Ion ConcentrationReceptors, GlucocorticoidVero CellsVirus ReplicationAntiviral AgentsDexamethasoneReceptors, GlucocorticoidSLC9A3 protein, humanSodium-Hydrogen Exchanger 3coronavirusdexamethasoneinfectious bronchitis virusNa+/H+exchanger 3pH

Identifiers

PMID40340398
PMCPMC12172481

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.