Evidence map›Paper›PMID 40340543›Full record

ArticleBMC genomics2025

Screening of molecular markers associated with hornless traits in Qira black sheep.

Wen Zhou, Lijun Zhu, Yuwei Peng, Xiaopeng Li, Xuechen Zhang, Zhipeng Han, Jingping Li, Xinyu Bai, Qifeng Gao, Ruizhi Yang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wen ZhouCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Lijun ZhuCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Yuwei PengCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Xiaopeng LiCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Xuechen ZhangCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Zhipeng HanCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Jingping LiCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Xinyu BaiCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Qifeng GaoCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Ruizhi YangCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China.
Tao JiangCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China. jiangtao888888@126.com.
Shudong LiuCollege of Animal Science and Technology, Tarim University, Xinjiang, 843300, China. liushudong63@126.com.

Funding

Bingtuan Science and Technology Program 2022CB001-09Division city key areas of science and technology research projects S2023LY00007Technical System for Selection and Promotion of Local Meat Sheep Breeds in the Pastoral Areas of the Autonomous Region MQTX-11
6 · The paper itself

Abstract

Hornless trait in sheep is one of the important traits affecting their economic production efficiency. In order to screen the molecular markers related to hornless trait in Qira black sheep, we used Illumina Ovine 50 K SNP chip data of 189 Qira black sheep, which were divided into two groups based on their horned and hornless traits. GWAS analysis of individuals of interest. Used the horned trait group as the reference group, and performed xp-EHH analysis with the hornless group. The hornless group was subjected to iHS and Pi analyses. After annotating the relevant candidate regions based on the sheep 4.0 genome microarray data. 681 candidate genes were obtained from the xp-EHH analysis, 87 candidate genes from the iHS analysis, and 2,171 candidate genes from the Pi analysis. A total of 19 candidate genes were obtained from further analysis of the candidate regions. Candidate genes were analyzed by GO and KEGG, and RXFP2, TNS3, EYA2 and OCSTAMP genes were found to be associated with horned traits in Qira black sheep. Further PCR validation of RXFP2 revealed that loci 10: 29,501,280 (P = 0.002), 10: 29,501,431 (P = 0.003) and 10: 29,051,333 (P = 0.0001) were significantly associated with hornless trait in Qira black sheep.

Indexed as

HornsSheep, DomesticAnimalsGenetic MarkersGenome-Wide Association StudyPhenotypePolymorphism, Single NucleotideQuantitative Trait LociSheepGenetic MarkersCandidate geneHornless traitQira black sheepSelection signal analysis

Identifiers

PMID40340543
PMCPMC12063373

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.