Evidence map›Paper›PMID 40340640›Full record

ArticleJournal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology2025

Simvastatin-loaded liposomal nanoparticles as treatment for adenomyosis in a patient-derived xenograft mouse model: a pilot study.

Rachel Michel, Kathleen L Vincent, Gregory W Kirschen, Massoud Motamedi, Jamal Saada, Jinping Yang, Bulent Ozpolat, Gokhan S Kilic, Mostafa A Borahay

Abstract read
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In one paragraph

Article in Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rachel MichelDepartment of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD, USA.
Kathleen L VincentDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Gregory W KirschenDepartment of Obstetrics & Gynecology, University of Pennsylvania, Philadelphia, PA, USA.
Massoud MotamediDepartment of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA.
Jamal SaadaDepartment of Anesthesiology, University of Texas Medical Branch, Galveston, TX, USA.
Jinping YangDepartment of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX, USA.
Bulent OzpolatDepartment of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA.
Gokhan S KilicDepartment of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, TX, USA.
Mostafa A BorahayDepartment of Gynecology & Obstetrics, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-0554-132X

Funding

UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
WOMEN'S REPRODUCTIVE HEALTH RESEARCH CENTERK12HD001269 · NICHD · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HANKINS, GARY D · 1998 to 2013
$5.0M
Mechanisms of actions(s) of simvastatin in uterine leiomyomaR01HD094380 · NICHD · JOHNS HOPKINS UNIVERSITY · PI BORAHAY, MOSTAFA A. · 2018 to 2022
$4.0M
Role of senescent cells in uterine fibroid pathogenesisR01HD111243 · NICHD · JOHNS HOPKINS UNIVERSITY · PI Mostafa A. Borahay, JENNIFER H ELISSEEFF · 2023 to 2026
$3.2M
NCATS NIH HHS UL1 TR000071NICHD NIH HHS K12 HD001269NICHD NIH HHS R01 HD094380NICHD NIH HHS R01 HD111243
6 · The paper itself

Abstract

backgroundAdenomyosis is a common gynaecological condition where ectopic endometrial glands and stroma grow within the myometrium. This condition has a high clinical burden impacting those afflicted with debilitating symptoms including heavy painful periods. Simvastatin is an oral hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, typically used to treat hyperlipidaemia. Simvastatin has recently shown promise for treating gynaecological conditions such as endometriosis and uterine fibroids with nanoliposomal formulations demonstrating improved efficacy. In this pilot study, we tested simvastatin-loaded liposomal nanoparticles on xenografted adenomyosis tissues in a patient-derived mouse model.

methodsWe surgically inserted oestrogen/progesterone pellets into mice, followed by adenomyosis tissue xenografts 15 days later. Mice were then randomised into three groups: control, simvastatin, and simvastatin-loaded liposomal nanoparticles (simvastatin-NP). We quantified the changes in adenomyosis xenograft size weekly using a calliper as well as ultrasound imaging 28 days after treatment, prior to sacrifice. We also measured the proliferation of biomarker Ki67 in the xenografted tissues using immunohistochemistry after animal sacrifice.

resultsTreatment with simvastatin-NP significantly reduced volume and weight of adenomyosis xenografts while attenuating Ki67 expression when compared to the control and simvastatin groups.

Indexed as

AdenomyosisHydroxymethylglutaryl-CoA Reductase InhibitorsNanoparticlesSimvastatinAnimalsDisease Models, AnimalFemaleHumansKi-67 AntigenLiposomesMicePilot ProjectsHydroxymethylglutaryl-CoA Reductase InhibitorsKi-67 AntigenLiposomesSimvastatinAdenomyosisnanoparticles, animalsimvastatin

Identifiers

PMID40340640
PMCPMC12168516

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.