Evidence map›Paper›PMID 40340714›Full record

ReviewFuture oncology (London, England)2025

Overcoming barriers to advanced biomolecular technologies that inform treatment of solid tumors: a roadmap to access.

Jesús Garcia-Foncillas, Arnaud Bayle, Dirk Arnold, Bernard Avouac, Ahmad Awada, Luis de la Cruz-Merino, Åslaug Helland, Ulrik Lassen, Pierre Laurent-Puig, Nicola Normanno and 3 more

Abstract readReview
In one paragraph

Review in Future oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jesús Garcia-FoncillasUniversity Cancer Institute & The Department of Oncology, University Hospital Fundacion Jimenez Diaz, Autonomous University, Madrid, Spain.
Arnaud BayleBureau Biostatistique et Epidémiologie, Gustave Roussy, Université Paris-Saclay, Villejuif, France.
Dirk ArnoldAsklepios Tumorzentrum Hamburg, AK Altona, Hamburg, Germany.
Bernard AvouacC2A Market Access Consulting, Paris, France.
Ahmad AwadaOncology Medicine Department, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
Luis de la Cruz-MerinoCancer Immunotherapy, Biomedicine Institute of Seville (IBIS)/CSIC, Clinical Oncology Department, University Hospital Virgen Macarena and School of Medicine, University of Seville, Seville, Spain.
Åslaug HellandDivision of Cancer Medicine, Oslo University Hospital, University of Oslo, Oslo, Norway.
Ulrik LassenRigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Pierre Laurent-PuigInstitut du Cancer Paris Carpem; APHP, Université Paris Cité, Paris, France.
Nicola NormannoScientific Directorate, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", Meldola, Italy.
Kristoffer RohrbergRigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Julien TaiebGI Oncology Department, Georges Pompidou European Hospital SIRIC-CARPEM, Université Paris Cité, Paris, France.
Albrecht StenzingerInstitute of Pathology and Center for Personalized Medicine (ZPM), University Hospital Heidelberg, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of advanced biomolecular technologies for detecting molecular and genomic signatures of individual tumors has transformed oncology care, introducing proven methodologies that can inform treatment with matched targeted therapies and predict response at the individual patient level. However, access to these technologies has been hampered by multiple barriers, most notably price and obtainability. Other barriers include lack of knowledge of available technologies, concerns about value, and outdated infrastructures that impede critical operations within the clinic or laboratory. Accessibility barriers to advanced biomolecular testing are critically important to patient care, as new technological advances in molecular medicine continue to outpace the implementation of solutions. Given the proven evidence for improved patient outcomes with precision oncology medicines, it is imperative to understand the value afforded by these technologies. The purpose of this narrative review is to describe existing and emerging barriers to access and present a "roadmap to access" that will facilitate the urgently needed discussions to identify solutions for improving access. Implementation of these solutions will raise awareness of available technologies and treatments and their prognostic significance, improve evidence collection for demonstration of value, and fortify clinical and laboratory infrastructure and operations.

Indexed as

Health Services AccessibilityNeoplasmsPrecision MedicineBiomarkers, TumorGenomicsHumansMolecular Targeted TherapyBiomarkers, Tumoraccessbarriersbiomarkersbiomolecular technologydiagnosticsPrecision oncologyprognosticvalue

Identifiers

PMID40340714
PMCPMC12150629

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.