Evidence map›Paper›PMID 40340839›Full record

ArticleLipids in health and disease2025

Association between relative fat mass and cognitive function among US older men: NHANES 2011-2014.

Linlin Liu, Anshi Wu, Shengnan Yang

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PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Linlin LiuDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.
Anshi WuDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China. AnshiWu123@outlook.com.
Shengnan YangDepartment of Anesthesiology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRelative fat mass (RFM) is a new metric developed to assess the entire body fat proportion in adults. The objective of this study was to examine the correlation between cognitive performance and RFM in older American males.

methodsA total of 1,321 individuals were selected from the National Health and Nutrition Examination Survey (NHANES) that was carried out between the years 2011 and 2014. Specifically, the Consortium to Establish a Registry for Alzheimer's Disease Word Learning Test (CERAD-WL), the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST) were used in order to achieve the objective of assessing cognitive function. The standardized scores of the three previously mentioned tests were averaged to create the Z-scores, a composite, generalized metric. RFM was ascertained by measuring waist circumference (WC) and height. The relationships that exist between RFM and cognitive performance were investigated using a variety of statistical methods, including multivariate linear regression, threshold effect analyses, smooth curve fitting, and subgroup analyses.

resultsThe study included 1,321 male volunteers aged 60 years or older, and comprehensive data was provided for each individual. Fully adjusted models indicated a negative correlation between RFM and CERAD-WL scores[-0.17, (-0.32,-0.01)], DSST scores[-0.83, (-1.16,-0.50)] and Z-scores[-0.03, (-0.05, -0.01)]. It was observed that the negative correlation that exists between RFM and Z-scores became more pronounced when RFM exceeded 35.78. Furthermore, subgroup analyses showed that the association between RFM and cognitive function was significantly impacted by education level, poverty-income ratio (PIR), smoking status, and drinking status.

conclusionsA higher RFM was linked to lower cognitive function in older men, suggesting that management of RFM may prove advantageous in mitigating cognitive decline among older male populations.

Indexed as

Adipose TissueCognitionAgedAged, 80 and overBody Mass IndexHumansMaleMiddle AgedNutrition SurveysUnited StatesWaist CircumferenceCognitive functionNHANESObesityOlder menRelative Fat Mass(RFM)

Identifiers

PMID40340839
PMCPMC12060541

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.