Evidence map›Paper›PMID 40341096›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

[

Qunchao Zhao, Jeih-San Liow, Joo Eun Jee, Jose Montero Santamaria, Matilah Pamie-George, Cheryl Morse, Shawn Wu, Sami S Zoghbi, Sung Won Kim, Robert B Innis and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qunchao ZhaoMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Jeih-San LiowMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Joo Eun JeeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Jose Montero SantamariaMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Matilah Pamie-GeorgeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Cheryl MorseMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Shawn WuMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Sami S ZoghbiMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Sung Won KimMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Robert B InnisMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.
Victor W PikeMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland pikev@mail.nih.gov telus@mail.nih.gov.
Sanjay TeluMolecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland pikev@mail.nih.gov telus@mail.nih.gov.

Funding

PET Radiopharmaceutical SciencesZIAMH002793 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PIKE, VICTOR W · 2009 to 2025
$69.8M
Translational Evaluation Of PET RadiotracersZIAMH002795 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI INNIS, ROBERT · 2009 to 2025
$32.0M
Intramural NIH HHS ZIA MH002793Intramural NIH HHS ZIA MH002795
6 · The paper itself

Abstract

Phosphodiesterase type 4 subtype B (PDE4B) selectively hydrolyzes cyclic adenosine monophosphate to enact numerous downstream signaling events. PDE4B is widely expressed in the brain and is implicated in several neuropsychiatric disorders. Moreover, PDE4B inhibition shows antiinflammatory and antidepressant-like effects in animal studies. [

Indexed as

BrainCarbon RadioisotopesCyclic Nucleotide Phosphodiesterases, Type 4Positron-Emission TomographyPyrazinesAnimalsLigandsMacaca mulattaMaleRadiopharmaceuticalsRatsRats, Sprague-DawleyTissue DistributionCarbon-11Carbon RadioisotopesCyclic Nucleotide Phosphodiesterases, Type 4LigandsPyrazinesRadiopharmaceuticals[11C]ZTP-1monkeyPDE4BPETrat

Identifiers

PMID40341096
PMCPMC12212184

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.