Evidence map›Paper›PMID 40341601›Full record

ArticleGeroScience2026

Neuroprotective mechanism of hydrogen sulfide in okadaic acid-induced alzheimer-like pathology.

Pradip K Kamat, Anuradha Kalani, Nabendu Debnath, Zayd Mushtaq, Suresh C Tyagi, Neetu Tyagi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Integrative Transcriptomics and Mendelian Randomization IdentifyCurrent issues in molecular biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pradip K KamatDepartments of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, 30912, USA.
Anuradha KalaniDisease Biology Lab and Molecular Oncology Lab, Department of Life Science and Biotechnology, Chhatrapati Shahu Ji Maharaj University, Kanpur, 208024, India.
Nabendu DebnathCentre for Molecular Biology, Central University of Jammu, Bagla (Raya-Suchani), District Samba, 181143, Jammu & Kashmir, India.
Zayd MushtaqDepartment of Physiology, School of Medicine, Health Sciences Center, University of Louisville, A- 1201, Louisville, KY, 40202, USA.
Suresh C TyagiDepartment of Physiology, School of Medicine, Health Sciences Center, University of Louisville, A- 1201, Louisville, KY, 40202, USA.
Neetu TyagiDepartment of Physiology, School of Medicine, Health Sciences Center, University of Louisville, A- 1201, Louisville, KY, 40202, USA. n0tyag01@louisville.edu.

Funding

American Heart Association 24TPA1304527American Heart Association 971566
6 · The paper itself

Abstract

Okadaic acid (OKA) is a marine biotoxin that accumulates in shellfish and is responsible for causing diarrheic shellfish poisoning. OKA is a powerful and selective inhibitor of serine/threonine phosphatases 1 and 2A, which induces hyperphosphorylation of tau in vitro and in vivo leading to Alzheimer's disease (AD)-like pathology and memory impairment. Hydrogen sulfide (H

Indexed as

Alzheimer DiseaseHydrogen SulfideNeuroprotective AgentsOkadaic AcidAnimalsDisease Models, AnimalGlycogen Synthase Kinase 3 betaMaleMiceMice, Inbred C57BLPhosphorylationSignal Transductiontau ProteinsGlycogen Synthase Kinase 3 betaHydrogen SulfideNeuroprotective AgentsOkadaic Acidtau ProteinsAlzheimer’s diseaseCerebral blood flowCognitive impairmentHydrogen sulfide donorNeurodegenerationOkadaic acidSynaptic remodeling

Identifiers

PMID40341601
PMCPMC12972395

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.