Evidence map›Paper›PMID 40342000›Full record

ReviewHistology and histopathology2026

The evolution of mast cells across all vertebrate classes: The mystery continues.

Stefano Bacci

Abstract readReview
PubMed Publisher
In one paragraph

Review in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Interactions Between Tryptase-Positive Mast Cells and Melanin-AInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Role of Mast Cells and Their Mediators in Chronic Kidney Diseases.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Impact ofJournal of inflammation research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Stefano BacciDepartment of Biology, Research Unit of Histology and Embryology, University of Florence, Florence, Italy. stefano.bacci@unifi.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The paper examines what the mast cell, a cell that arose in urochordates and reached humans with the same morphological profile, is used for. Activated mast cells contribute to the regulation of the local immune response and major inflammation and healing processes with the help of a broad range of mediators. Located primarily at the interface between the host and the external environment, mast cells are widely distributed. The local microenvironment directly affects mast cell development, phenotype, and function, which in turn affects the cells' capacity to identify and react to different stimuli by releasing a variety of physiologically active mediators. By interacting with a range of other cells involved in physiological and immunological responses, mast cells can react to changes in their surroundings and serve as first responders in dangerous situations. Consequently, the mast cell's crucial function in innate and adaptive immunity, including immunological tolerance, has come to light more frequently. On the other hand, mast cell malfunction has identified these cells as the primary culprits in a number of autoimmune illnesses, cancer, and chronic allergic/inflammatory conditions.

Indexed as

Biological EvolutionMast CellsVertebratesAnimalsHumans

Identifiers

PMID40342000

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.