Evidence map›Paper›PMID 40342271›Full record

ArticleActa physiologica (Oxford, England)2025

SorCS2 Is Important for Astrocytic Function in Neurovascular Signaling.

Christian Staehr, Hande Login, Elizaveta V Melnikova, Magdalena Bakun, Ewelina Ziemlinska, Lilian Kisiswa, Simin Berenji Ardestani, Stella Solveig Nolte, Hans Christian Beck, Line Mathilde Brostrup Hansen and 5 more

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In one paragraph

Article in Acta physiologica (Oxford, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Christian StaehrDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Hande LoginDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Elizaveta V MelnikovaDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Magdalena BakunMass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.ORCID https://orcid.org/0000-0001-8542-2234
Ewelina ZiemlinskaCellular Neurobiology Research Group, Faculty of Biology, Institute of Developmental Biology and Biomedical Sciences, University of Warsaw, Warsaw, Poland.
Lilian KisiswaDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Simin Berenji ArdestaniDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Stella Solveig NolteDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Hans Christian BeckDepartment of Clinical Biochemistry, Odense University Hospital, Odense, Denmark.
Line Mathilde Brostrup HansenDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Dmitry PostnovDepartment of Clinical Medicine, Center of Functionally Integrative Neuroscience, Aarhus University Hospital Skejby, Aarhus, Denmark.
Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.ORCID https://orcid.org/0000-0003-2592-9898
Anna R MalikCellular Neurobiology Research Group, Faculty of Biology, Institute of Developmental Biology and Biomedical Sciences, University of Warsaw, Warsaw, Poland.ORCID https://orcid.org/0000-0001-7732-0756
Anders NykjaerDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.
Vladimir V MatchkovDepartment of Biomedicine, Aarhus University, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3303-1095

Funding

Danish National Research Foundation DNRF133Danmarks Frie Forskningsfond 3101-00103BDanmarks Frie Forskningsfond 7016-00261Lundbeck FoundationLundbeck Foundation R248-2017-431Lundbeck Foundation R344-2020-952Lundbeck Foundation R412-2022-449Lundbeck Foundation R90-2011-7723Narodowe Centrum Nauki 2020/37/B/NZ3/00761The Excellence Initiative-Research University, the action I.3.4, the Programme at the University of Warsaw
6 · The paper itself

Abstract

introductionThe receptor SorCS2 is involved in the trafficking of membrane receptors and transporters. It has been implicated in brain disorders and has previously been reported to be indispensable for ionotropic glutamatergic neurotransmission in the hippocampus.

aimWe aimed to study the role of SorCS2 in the control of astrocyte-neuron communication, critical for neurovascular coupling.

methodsBrain slices from P8 and 2-month-old wild-type and SorCS2 knockout (Sorcs2

resultsSorCS2 was strongly expressed in astrocytes, primarily in their endfeet, of P8 mice; however, it was sparsely represented in 2-month-old mice. Sorcs2

conclusionThe results suggest that SorCS2 expression is important for the development of neurovascular coupling, at least in part by modulating glutamatergic and calcium signaling in astrocytes.

Indexed as

AstrocytesNeurovascular CouplingAnimalsBrainMiceMice, Inbred C57BLMice, KnockoutNeuronsSignal Transductionastrocytescalcium signalingglutamate signalingneurovascular couplingSorCS2

Identifiers

PMID40342271
PMCPMC12060088

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.