Evidence map›Paper›PMID 40342368›Full record

SynthesisFrontiers in nutrition2025

Probiotics as technological innovations in psychiatric disorders: patents and research reviews.

Alyne Almeida de Lima, Sthefane Silva Santos, Mykaella Andrade de Araújo, Gabriel Vinderola, Cristiane Flora Villarreal, Max Denisson Maurício Viana

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alyne Almeida de Lima *Gonçalo Moniz Institute, Oswaldo Cruz Foundation-FIOCRUZ, Salvador, Brazil.
Sthefane Silva Santos *School of Pharmacy, Federal University of Bahia, Salvador, Brazil.
Mykaella Andrade de AraújoCollege of Medicine, Federal University of São Francisco Valley, Paulo Afonso, Brazil.
Gabriel VinderolaFaculty of Chemical Engineering, Institute of Industrial Lactology, Universidad Nacional del Litoral, Santa Fe, Argentina.
Cristiane Flora VillarrealGonçalo Moniz Institute, Oswaldo Cruz Foundation-FIOCRUZ, Salvador, Brazil.
Max Denisson Maurício VianaSchool of Pharmacy, Federal University of Bahia, Salvador, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Probiotics have shown promising results in treating anxiety and depression by modulating the gut-brain-microbiota axis using probiotics, which has motivated increasing commercial and academic interest in innovations and the probiotic market. This work explored innovation trends in the use of probiotics in the management of anxiety and depression, through a patent search performed in the Espacenet patent database. To expand the discussion, an additional search was performed on ClinicalTrials.gov and ScienceDirect. Recently probiotic innovations developed were deposited as pharmaceutical products (24.1%), functional foods (20.4%), or both (51.8%). Probiotic strains showed anxiolytic, antidepressant or both effects related to one or more mechanisms including modulation of neurotransmitters (61.1%), neuroendocrine mediators (35.2%) or neuroinflammation and oxidative stress (20.3%). The effects mainly were related to strains of the

Indexed as

antidepressantanxiolyticinnovationpatentprobioticsreview

Identifiers

PMID40342368
PMCPMC12060171

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.