Evidence map›Paper›PMID 40343169›Full record

ArticleMaterials today. Bio2025

Polymer oxidation: A strategy for the controlled degradation of injectable cryogels.

Alexandra Nukovic, Mohammad Hamrangsekachaee, Mahalakshmi Rajkumar, Gwyneth Wong, Emily R Tressler, Sara M Hashmi, Stephen M Hatfield, Sidi A Bencherif

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. HomologousMaterials today. Bio · 2026
    Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexandra NukovicDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Mohammad HamrangsekachaeeDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Mahalakshmi RajkumarDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Gwyneth WongDepartment of Biology, Northeastern University, Boston, MA, 02115, USA.
Emily R TresslerDepartment of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
Sara M HashmiDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Stephen M HatfieldDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Sidi A BencherifDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.

Funding

Overcoming vaccine-associated hypoxia with advanced biomaterials to enhance cancer immunotherapyR01EB027705 · NIBIB · NORTHEASTERN UNIVERSITY · PI HATFIELD, STEPHEN MATTHEW · 2021 to 2024
$1.9M
NIBIB NIH HHS R01 EB027705
6 · The paper itself

Abstract

Cryogels, an advanced subclass of hydrogels, are widely used in biomedical applications such as tissue engineering, drug delivery, and immunotherapy. Biopolymers, like hyaluronic acid (HA), are key building blocks for cryogel fabrication due to their intrinsic biological properties, biocompatibility, and biodegradability. HA undergoes biodegradation through hydrolysis, enzymatic degradation, and oxidation, but becomes less susceptible to degradation once chemically modified. This modification is necessary for producing HA-based cryogels with unique properties, including an open macroporous network, mechanical resilience, shape memory, and syringe injectability. Endowing cryogels with resorbable features is essential for meeting regulatory requirements and improving treatment outcomes. To this end, HA was oxidized with sodium periodate (HA

Indexed as

BiocompatibilityCryogelDegradationHydrolysisOxidation

Identifiers

PMID40343169
PMCPMC12059720

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.