ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2025
Super Movers: Epidemiology and Biology of a Novel Exceptional Aging Phenotype.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlthough gait speed typically declines with age, some individuals manage to maintain higher walking speeds well into older age. To better understand healthy longevity, we propose a novel exceptional aging phenotype of super movers, individuals 80 years or older with walking speeds comparable to individuals 3 decades younger.
methodsWe conducted a retrospective cohort study to examine the epidemiology and determinants of super mover status as well as mortality, biological aging and gait speed trajectories of super movers compared to age peers identified from 15 aging cohort studies across 24 countries.
resultsIn a pooled cohort of data from multicountry population-based surveys, prevalence of super movers ranged from 4.9% to 11.1% in individuals 80 and older, with an average overall prevalence of 7.3%. Compared to age peers, super movers exhibited lower disease prevalence, healthier lifestyles and had lower mortality rates (hazard ratios: 0.38, 95% CI: 0.09-0.66). In 2 smaller samples with gait and biological aging data and longitudinal gait assessments, compared to age-matched peers, super movers had younger biological age and showed faster gait speed from their seventh to tenth decades, respectively.
conclusionsSuper movers are an exceptional aging phenotype enriched with unique biological and clinical profiles that can provide valuable insights into healthy longevity.
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