Evidence map›Paper›PMID 40344182›Full record

ReviewThe Plant cell2025

The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.

Chandler A Sutherland, Danielle M Stevens, Kyungyong Seong, Wei Wei, Ksenia V Krasileva

Abstract readReview
In one paragraph

Review in The Plant cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Structural Variation and Its Roles in Plant Genomes.Plants (Basel, Switzerland) · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. mamp-ml: A deep learning approach to epitope immunogenicity in plants.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chandler A SutherlandDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-5840-7661
Danielle M StevensDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0001-5630-137X
Kyungyong SeongDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-7711-0107
Wei WeiDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA.ORCID 0000-0002-1337-5253
Ksenia V KrasilevaDepartment of Plant and Microbial Biology, University of California Berkeley, Berkeley, CA 94720, USA.

Funding

Cross-kingdom health: evolution of innate immune receptors and their targetsDP2AT011967 · NCCIH · UNIVERSITY OF CALIFORNIA BERKELEY · PI KRASILEVA, KSENIA V · 2021 to 2024
$2.2M
Berkeley BioEnginuity FellowshipGrace Kase-Tsujimoto Graduate FellowshipNCCIH NIH HHS DP2 AT011967NIH Director's AwardNIH Director's Award 1DP2AT011967-01
6 · The paper itself

Abstract

Plants rely on germline-encoded, innate immune receptors to sense pathogens and initiate the defense response. The exponential increase in quality and quantity of genomes, RNA-seq datasets, and protein structures has underscored the incredible biodiversity of plant immunity. Arabidopsis continues to serve as a valuable model and theoretical foundation of our understanding of wild plant diversity of immune receptors, while expansion of study into agricultural crops has also revealed distinct evolutionary trajectories and challenges. Here, we provide the classical context for study of both intracellular nucleotide-binding, leucine-rich repeat receptors and surface-localized pattern recognition receptors at the levels of DNA sequences, transcriptional regulation, and protein structures. We then examine how recent technology has shaped our understanding of immune receptor evolution and informed our ability to efficiently engineer resistance. We summarize current literature and provide an outlook on how researchers take inspiration from natural diversity in bioengineering efforts for disease resistance from Arabidopsis and other model systems to crops.

Indexed as

ArabidopsisCrops, AgriculturalDisease ResistancePlant ImmunityReceptors, ImmunologicDNA, PlantGene Expression Regulation, PlantPlant DiseasesPlant ProteinsReceptors, Pattern RecognitionRNA, PlantDNA, PlantPlant ProteinsReceptors, ImmunologicReceptors, Pattern RecognitionRNA, Plant

Identifiers

PMID40344182
PMCPMC12118082

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.