Evidence map›Paper›PMID 40344291›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2026

Towards the Development of a Conceptual Framework of the Determinants of Pre-Eclampsia: A Hierarchical Systematic Review of Biomarkers.

Terteel Elawad, Hiten D Mistry, Mai-Lei Woo Kinshella, Marianne Vidler, Marie-Laure Volvert, Helen Elwell, Veronique Filippi, Kelly Pickerill, Rachel Craik, Joel Singer and 7 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Determinants of Pre-Eclampsia: Advancing a Conceptual Framework.BJOG : an international journal of obstetrics and gynaecology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Terteel ElawadDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Hiten D MistryDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Mai-Lei Woo KinshellaDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0001-5846-3014
Marianne VidlerDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Marie-Laure VolvertDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Helen ElwellBMA Library, British Medical Association, London, UK.
Veronique FilippiFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Kelly PickerillDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Rachel CraikDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0001-7885-0775
Joel SingerSchool of Population and Public Health, Centre for Health Evaluation and Outcome Sciences, University of British Columbia, Vancouver, British Columbia, Canada.
Rosemary TownsendCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
Hannah BlencoweFaculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK.
Eleni Z TsigasPreeclampsia Foundation, Melbourne, Florida, USA.
Jeffrey N BoneDepartment of Obstetrics and Gynaecology, BC Children's and Women's Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0001-7704-1677
Peter von DadelszenDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0003-4136-3070
Laura A MageeDepartment of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID https://orcid.org/0000-0002-1355-610X
PRECISE Network

Funding

Canadian Institutes of Health Research (CIHR)NIHR-Wellcome Partnership for Global Health Research Collaborative Award 217123/Z/19/ZUK Research and Innovation MR/P027938/1Wellcome Trust
6 · The paper itself

Abstract

backgroundPre-eclampsia is a leading cause of maternal and perinatal morbidity and mortality. There are several determinants of individual pregnant women's risk of developing pre-eclampsia, including biomarkers and ultrasound markers.

objectiveA conceptual framework to collate and summarise the extensive body of literature on biomarkers (including ultrasound markers) associated with pre-eclampsia, through a hierarchical systematic literature review. SEARCH STRATEGY: Medline, Embase, Health Technology Assessments, Database of Abstracts of Reviews of Effects, Cochrane Library were searched until April 2024. SELECTION CRITERIA: Reviews and cohort studies (> 100 participants) reporting biomarkers associated with pre-eclampsia were included. DATA COLLECTION AND ANALYSIS: Studies were screened by title, then abstract and full text. Evidence was prioritised from umbrella reviews, followed by systematic reviews and then observational studies. Associations were assessed for strength of association and quality of evidence using GRADE. MAIN

resultsThe biomarker domain included 40 individual determinants of pre-eclampsia. Of these, there were 18 biomarkers with definite or probable associations based on moderate-strong quality evidence across markers of angiogenic imbalance, fetal-placental unit function, inflammatory and immune markers, and physiological markers. Vascular endothelial growth factor, human chorionic gonadotropin, inhibin-A, maternal serum placental protein-13, and interferon-gamma had definite associations based on high-quality evidence.

conclusionBiomarkers associated with the development of pre-eclampsia highlight the multi-factorial aetiology of the syndrome. The addition of biomarkers, including ultrasound, will optimise the prediction of pre-eclampsia and enable individualised risk stratification.

Indexed as

BiomarkersPre-EclampsiaFemaleHumansPregnancyBiomarkersBiomarkersConceptual frameworkPre‐eclampsia

Identifiers

PMID40344291
PMCPMC13572888

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.