Evidence map›Paper›PMID 40344385›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Reversal of Stress-Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment.

Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yuwen LuMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Sibo JiangInstitute of Genetics and Reproduction, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Ting ShenMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Yuan ZhangInstitute of Genetics and Reproduction, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Chengbin HeDepartment of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Yun GaoInstitute of Genetics and Reproduction, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Liyin ShenMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Qiao JinInstitute of Genetics and Reproduction, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Yuting ZhaoInstitute of Genetics and Reproduction, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Ping LiangKey Laboratory of Combined Multiorgan Transplantation, Ministry of Public Health, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310003, China.
Chaochen WangCentre of Biomedical Systems and Informatics, ZJU-UoE Institute, Zhejiang University School of Medicine, International Campus, Zhejiang University, Haining, 314400, China.
Hongjie HuDepartment of Radiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, 310016, China.
Jin HeInstitute of Genetics and Reproduction, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.
Kaicheng DengMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Shuo WangDigital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Yunhe ChenDigital Medical Research Center, School of Basic Medical Sciences, Fudan University, Shanghai, 200032, China.
Jun LingMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.ORCID https://orcid.org/0000-0002-0365-1381
Yang ZhuMOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China.ORCID https://orcid.org/0000-0002-7384-607X
Lenan ZhuangInstitute of Genetics and Reproduction, Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou, 310058, China.ORCID https://orcid.org/0000-0001-9561-8396

Funding

Alibaba-Zhejiang University Joint Research Center of Future Digital HealthcareHigh-level Talents Special Support Plan of Zhejiang Province 2021R52041Key Technologies Research and Development Program 2019YFE0117400Key Technologies Research and Development Program 2021YFA0805902"Leading Goose" R&D Program of Zhejiang 2024C03074Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2024KY1121National Natural Science Foundation of China 32000971National Natural Science Foundation of China 32270884National Natural Science Foundation of China 81873908National Natural Science Foundation of China 82202328State Key Laboratory of Transvascular Implantation Devices 012024018Zhejiang Provincial Natural Science Foundation of China LQ24H180006
6 · The paper itself

Abstract

Elevated expression of the mechanosensitive ion channel PIEZO1 in response to abnormal mechanical stimuli is implicated in many diseases, including myocardial infarction (MI). However, no effective strategy is currently available to normalize PIEZO1 expression for disease management. This study investigates the therapeutic potential of mechanically adapted cardiac patches in reversing PIEZO1 elevation and treating MI. Increased mechanical stress and PIEZO1 upregulation are observed in ischemic cardiomyopathy myocardium. Using finite element analysis, elastomeric patches are designed and applied on MI rats to reduce left ventricular (LV) wall stress and mitigate LV remodeling. Molecular analysis reveals that patch treatment suppresses stress-induced chromatin opening of the Piezo1 promoter, reversing PIEZO1 elevation and restoring heart contraction gene expression. The patch's therapeutic benefits correlate with the reversal of PIEZO1 elevation is further validated in a porcine model. Notably, constant high expression of endogenous PIEZO1 partially blocks the patch's therapeutic effects, confirming that the mechanism of patch treatment involves reversing PIEZO1 expression, in addition to providing physical support. In conclusion, cardiac patches reduce LV wall stress, preserving cardiac function and geometry by both physically supporting and biologically reversing PIEZO1 expression, highlighting the potential of medical devices in normalizing PIEZO1 expression and treating related diseases.

Indexed as

Ion ChannelsMyocardial InfarctionPericardiumAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyStress, MechanicalSwineVentricular RemodelingIon ChannelsPiezo1 protein, ratbiomechanical simulationcardiac patchmyocardial infarctionPIEZO1

Identifiers

PMID40344385
PMCPMC12279209

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.