Evidence map›Paper›PMID 40344482›Full record

ArticleJournal of biomedical materials research. Part A2025

PDGF-Releasing Hydrogels for Enhanced Proliferation of Human Nucleus Pulposus Cells.

Takanori Fukunaga, Joseph J Pearson, Ryan Cree Miller, Changli Zhang, Mohammed Lakrat, Lisbet Haglund, Martha Elena Diaz-Hernandez, Johnna S Temenoff, Hicham Drissi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical materials research. Part A, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. [Research progress of hydrogel-based growth factors for treatment of intervertebral disc degeneration].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Takanori Fukunaga *Musculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Joseph J Pearson *Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.
Ryan Cree Miller *Coulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.
Changli ZhangMusculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Mohammed LakratMusculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Lisbet HaglundDepartment of Surgery, McGill University, Montreal, Quebec, Canada.
Martha Elena Diaz-HernandezMusculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA.
Johnna S TemenoffCoulter Department of Biomedical Engineering, Georgia Tech/Emory University, Atlanta, Georgia, USA.ORCID 0000-0002-9066-7954
Hicham DrissiMusculoskeletal Institute, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0002-3322-281X

Funding

Control of intervertebral disc degeneration via matrix-mediated delivery of platelet-derived growth factorsR01AR076427 · NIAMS · EMORY UNIVERSITY · PI DRISSI, MOULAY HICHAM · 2021 to 2025
$2.0M
Department of Orthopaedcis, Emory UniversityNIAMS NIH HHS R01 AR076427NIH-R01AR076427
6 · The paper itself

Abstract

Hydrogels offer a promising solution for sustained and controlled drug delivery and cell-tissue biocompatibility. In the intervertebral disc (IVD), delivering growth factors faces challenges due to the antagonistic inflammatory environment and continuous mechanical stress, which can degrade biological agents and may reduce their local activity. To address this, we investigated the prolonged release of platelet-derived growth factor isoforms BB (PDGF-BB) and AB (PDGF-AB) by using N-desulfated heparin methacrylamide (Hep

Indexed as

BecaplerminHydrogelsNucleus PulposusPlatelet-Derived Growth FactorCell ProliferationCells, CulturedCell SurvivalHumansPolyethylene GlycolsBecaplerminHydrogelsPlatelet-Derived Growth Factorplatelet-derived growth factor ABPolyethylene Glycolsintervertebral disc degenerationnucleus pulposus cellsPEG hydrogelplatelet‐derived growth factor

Identifiers

PMID40344482
PMCPMC12129364

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.