SynthesisCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2025
Drug-Coated Balloons Versus Non-Coated Balloons for Side Branch Treatment in Bifurcation Lesions: A Systematic Review and Meta-Analysis.
Synthesis in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hybrid drug-coated balloon strategy for coronary bifurcation lesions: a systematic review and meta-analysis.BMJ open · 2026Pooled it
- Drug-Coated Balloon Angioplasty for Isolated Medina 0,0,1 Ostial Side-Branch Lesions: Procedural Outcomes, Bailout Stenting, and 12-Month Clinical Follow-Up.Medicina (Kaunas, Lithuania) · 2026Observational
- Drug-coated balloon angioplasty in coronary artery disease: state of the art review.NPJ cardiovascular health · 2026Review
- Drug-Coated Balloons in Coronary Bifurcation Disease: A State-of-the-Art Review.Journal of personalized medicine · 2026Review
- Side branch ballooning in provisional stenting of coronary bifurcation lesions: the case for a selective, imaging- and physiology-guided approach.Frontiers in cardiovascular medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary bifurcation lesions (CBL) account for ~20% of percutaneous coronary interventions (PCI). When using provisional stenting, optimal management of a diseased side branch (SB) remains debated. Drug-coated balloons (DCBs) are an emerging option, but data on their role in CBL PCI are limited.
aimsWe conducted a meta-analysis to compare DCBs and non-compliant balloons (NCBs) for SB treatment.
methodsA systematic search of MEDLINE, CENTRAL, and EmBase (until November 2024) identified studies comparing DCBs and NCBs for treating the SB. From 1451 studies, five were included (two randomized controlled trials [RCTs], three observational), with 1762 patients, predominantly male with acute coronary syndrome (ACS). The primary outcome was major adverse cardiac events (MACE); secondary outcomes included myocardial infarction (MI), target lesion revascularization (TLR), and target vessel revascularization (TVR).
resultsDCBs significantly reduced MACE (pooled OR 0.48, 95% CI 0.34-0.68, p < 0.0001, I² = 0%) and MI (pooled OR 0.39, 95% CI 0.25-0.62, p < 0.001, I² = 0%) compared to NCBs. No significant differences were observed in TLR or TVR. Subgroup analysis confirmed consistency across observational studies and RCTs for MACE and MI.
conclusionsDCBs in SB treatment during CBL PCI are associated with reduced MACE and MI compared to NCBs, with no significant differences in vessel-specific outcomes. These findings suggest a potential clinical benefit of DCBs in reducing ischemic events, while limiting stenting in CBL. Further research is needed to refine patient selection and optimize outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.