ArticleEnvironment international2025
Simultaneous profiling of mercapturic acids, glucuronic acids, and sulfates in human urine.
Article in Environment international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- A liquid chromatography- tandem mass spectrometry method for the analysis of oxidative stress, nitrative stress, metabolic, and inflammatory biomarkers in serum: comparison to urinary concentrations.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2026Article
- Comprehensive Profiling of Human Urinary Mercapturic Acid Conjugates Associated with Exposure to Reactive Chemical Species Using Enzymatic Deacetylation and High-Resolution Mass Spectrometry.Analytical chemistry · 2026Article
- A unified liquid chromatography-mass spectrometric approach combining targeted and untargeted analyses for community exposure profiling in wastewater.Environment international · 2026Article
- Retrospective Urine Metabolomics of Clinical Toxicology Samples Reveals Features Associated with Cocaine Exposure.Metabolites · 2025Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Humans are constantly exposed to both naturally-occurring and anthropogenic chemicals. Targeted mass spectrometry approaches are frequently used to measure a small panel of chemicals and their metabolites in environmental or biological matrices, but methods for comprehensive individual-level exposure assessment are limited. In this study, we applied an integrated library-guided analysis (ILGA) with ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF/MS) to profile phase II metabolites, specifically mercapturic acids (MAs), glucuronic acids (GAs), and sulfates (SAs) in human urine samples (n = 844). We annotated 424 metabolites (146 MAs, 171 GAs, 107 SAs) by querying chromatographic features with in-house structural libraries, filtering against fragmentation patterns (common neutral loss and ion fragment), and comparing mass spectra with in-silico fragmentations and external spectral libraries. These metabolites were derived from over 200 putative parent compounds of exogenous and endogenous sources, such as dietary compounds, benzene/monocyclic substituted aromatics, pharmaceuticals, polycyclic aromatic hydrocarbons, bile acids/bile salts, and 4-hydroxyalkenals associated with lipid peroxidation process. Further, we performed statistical analyses on 214 metabolites found in more than 75% of samples to examine the association between metabolites and demographic characteristics using integrated network analysis, principal component analysis (PCA), and multivariable linear regression models. The network analysis revealed four distinct communities of 37 positively correlated metabolites, and the PCA (using the 37 metabolites) presented 4 principal components that meaningfully explained at least 80% of the variance in the data. The multivariable linear regression models showed some positive and negative associations between metabolite profiles and certain demographic variables (e.g., age, sex, race, education, income, and tobacco use).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.