ArticleBiological psychiatry2026
Transdiagnostic and Disorder-Level Genome-Wide Association Studies Enhance Precision of Substance Use and Psychiatric Genetic Risk Profiles in African and European Ancestries.
Article in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Polygenic risk factors for comorbid diagnoses in individuals with substance use disorders: A phenome-wide survival analysis.Psychological medicine · 2026Article
- Isolating transdiagnostic effects reveals specific genetic profiles in psychiatric disorders.JCPP advances · 2026Article
- Shared genetic architecture of cortical morphology and psychiatric disorders: insights from a cross-trait analyses across 180 cortical regions.medRxiv : the preprint server for health sciences · 2026Article
- Machine learning-based predictive models and subtypes patterns in peripheral blood of schizophrenia based on a machine learning computational framework.Schizophrenia (Heidelberg, Germany) · 2026Article
- Prediction of opioid use disorder among patients with chronic non-cancer pain receiving long-term opioid therapy.Pain medicine (Malden, Mass.) · 2026Article
- Substance use disorders exhibit unique and disorder specific genetic associations with externalizing and internalizing psychopathology.medRxiv : the preprint server for health sciences · 2026Article
- Multivariate genetic analyses of 2.2 million individuals reveal broad and substance-specific pathways of addiction risk.Nature. Mental health · 2026Article
- Multivariate genetic of 2.2 million individuals demonstrate genetic influences on substance use disorders operate via behavioral disinhibition and substance-specific risk.medRxiv : the preprint server for health sciences · 2025Article
- Integrating HiTOP and RDoC frameworks Part I: Genetic architecture of externalizing and internalizing psychopathology.Psychological medicine · 2025Article
- Exploring the genetic and socioeconomic interplay between ADHD and anxiety disorders using Mendelian randomization.Frontiers in psychiatry · 2024Article
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Abstract
backgroundSubstance use disorders (SUDs) and psychiatric disorders frequently co-occur, and their etiology likely reflects both transdiagnostic (i.e., common/shared) and disorder-level (i.e., independent/nonshared) genetic influences. Understanding the genetic influences that are shared and those that operate independently of the shared risk could enhance precision in diagnosis, prevention, and treatment, but this remains underexplored, particularly in non-European ancestry groups.
methodsWe applied genomic structural equation modeling to examine the common and independent genetic architecture among SUDs and psychotic, mood, and anxiety disorders using summary statistics from genome-wide association studies (GWASs) conducted in European ancestry (EUR) and African ancestry (AFR) individuals. To characterize the biological and phenotypic associations, we used FUMA, conducted genetic correlations, and performed phenome-wide association studies (PheWASs).
resultsIn EUR individuals, transdiagnostic genetic factors represented SUDs, psychotic disorders, and mood/anxiety disorders, with a GWAS identifying 2 novel lead single nucleotide polymorphisms (SNPs) for the mood factor. In AFR individuals, genetic factors represented SUDs and psychiatric disorders, and a GWAS identified 1 novel lead SNP for the SUD factor. In EUR individuals, second-order factor models showed phenotypic and genotypic associations with a broad range of physical and mental health traits. Finally, genetic correlations and PheWASs highlighted how common and independent genetic factors for SUDs and psychotic disorders were differentially associated with psychiatric, sociodemographic, and medical phenotypes.
conclusionsCombining transdiagnostic and disorder-level genetic approaches can improve our understanding of co-occurring conditions and increase the specificity of genetic discovery, which is critical for identifying more effective prevention and treatment strategies to reduce the burden of these disorders.
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