Evidence map›Paper›PMID 40345969›Full record

ArticleChembiochem : a European journal of chemical biology2025

Synthesis and Evaluation of Pseudoglucosinolates Releasing Isothiocyanates in the Presence of Azoreductases.

Aishi Chakrabarti, Charity S G Ganskow, Mervic D Kagho, Claire C Jimidar, Lorenz Wiese, Neslihan Beyazit, Ulrike Beutling, Margarita Seeger, Silvana Smits, Stella Nyström and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chembiochem : a European journal of chemical biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aishi ChakrabartiDepartment of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden.ORCID https://orcid.org/0009-0002-9704-0801
Charity S G GanskowDepartment of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden.ORCID https://orcid.org/0000-0001-9779-4844
Mervic D KaghoDepartment of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-3714-7738
Claire C JimidarInstitute of Organic Chemistry, Technische Universität Braunschweig, Hagenring 30, 38106, Braunschweig, Germany.ORCID https://orcid.org/0000-0002-2737-4374
Lorenz WieseInstitute of Organic Chemistry, Technische Universität Braunschweig, Hagenring 30, 38106, Braunschweig, Germany.ORCID https://orcid.org/0009-0002-1416-6231
Neslihan BeyazitDepartment of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-5722-2400
Ulrike BeutlingDepartment for Chemical Biology, Helmholtz Center for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany.
Margarita SeegerInstitute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.ORCID https://orcid.org/0000-0002-5609-6844
Silvana SmitsDepartment of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden.ORCID https://orcid.org/0009-0006-0818-9006
Stella NyströmDepartment of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden.
Anne FarewellDepartment of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden.ORCID https://orcid.org/0000-0002-0841-4908
Anett SchallmeyInstitute of Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Spielmannstraße 7, 38106, Braunschweig, Germany.ORCID https://orcid.org/0000-0002-6670-0574
Mark BrönstrupDepartment for Chemical Biology, Helmholtz Center for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany.ORCID https://orcid.org/0000-0002-8971-7045
Philipp KlahnDepartment of Chemistry and Molecular Biology, University of Gothenburg, Natrium, Medicinaregatan 7B, 413 90, Gothenburg, Sweden.ORCID https://orcid.org/0000-0003-4713-2345

Funding

Deutsche Forschungsgemeinschaft KL3012/2-1Deutsche Forschungsgemeinschaft KL3012/4-1Fonds der Chemischen Industrie SK204/23Max-Buchner-Forschungsstiftung Max-Buchner FellowshipNiedersächsisches Ministerium für Wissenschaft und Kultur Smart Biotec ProgrammTUBITAKUniversity of Gothenburg Starting Funds
6 · The paper itself

Abstract

Naturally occurring isothiocyanates (ITCs) display multiple interesting bioactivities, but their medicinal exploitation is very limited as ITCs are non-druglike compounds with problematic pharmacokinetic properties. The concept of pseudoglucosinolates provides a novel prodrug approach for the release of ITCs which can be adjusted to different triggers such as enzymatic and chemical microenvironments. Herein, the first adaptation of this concept toward the release of ITCs in the presence of azoreductases within a turn-on fluorescence probe is reported and its applicability in covalent protein labeling is underlined.

Indexed as

IsothiocyanatesNADH, NADPH OxidoreductasesProdrugsFluorescent DyesMolecular StructureNitroreductasesazoreductaseFluorescent DyesIsothiocyanatesNADH, NADPH OxidoreductasesNitroreductasesProdrugsartificial glucosinolatesazoreductasebio‐responsive protein labelingsisothiocyanatespseudo glucosinolates

Identifiers

PMID40345969
PMCPMC12177692

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.