Evidence map›Paper›PMID 40346031›Full record

ArticlePhysiological reports2025

Therapeutic hyperthermia promotes lipid export and HSP70/90 during machine perfusion of human livers.

Adam M Thorne, Yana Geng, Veerle A Lantinga, Marieke Smit, Jan Albert Kuivenhoven, Robert J Porte, Folkert Kuipers, Peter Olinga, Justina C Wolters, Vincent E de Meijer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Adam M ThorneDepartment of Liver Transplantation and HPB Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Yana GengDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands.
Veerle A LantingaDepartment of Liver Transplantation and HPB Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Marieke SmitDepartment of Pediatrics, University of Groningen, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Jan Albert KuivenhovenDepartment of Pediatrics, University of Groningen, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Robert J PorteDepartment of Liver Transplantation and HPB Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Folkert KuipersEuropean Research Institute for the Biology of Ageing (ERIBA), University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Peter OlingaDepartment of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-4855-8452
Justina C WoltersDepartment of Pediatrics, University of Groningen, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Vincent E de MeijerDepartment of Liver Transplantation and HPB Surgery, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.ORCID 0000-0002-7900-5917

Funding

Ministerie van Economische Zaken en Klimaat (EZK) PPP31 2019-024Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO) 09150161810030Nederlandse Vereniging voor Gastroenterologie (NVGE) 01-2021Noaber Foundation (NF)
6 · The paper itself

Abstract

Liver transplantation is the only curative option for end-stage liver disease. Donor shortages necessitate the use of higher risk donor livers, including fatty livers, which are more susceptible to ischemia-reperfusion injury. Machine perfusion has improved graft utilization and is typically performed at hypothermic (8-12°C) or normothermic (35-37°C) temperatures. Here we studied the impact of mild hyperthermia (40°C) as a therapeutic intervention for fatty livers using in-depth proteomic and lipoprotein profiling of whole organ perfusion and precision-cut liver slices. We observed proteomic changes with metabolic alterations over time, evidenced by a significant increase in lipid export in whole organ perfusions. Furthermore, PCLS showed significant upregulation of metabolic processes and heat shock protein response after 24 h of hyperthermia. Machine perfusion under hyperthermic conditions may be a potential strategy to improve the utilization of fatty liver grafts, ultimately expanding the donor pool and improving transplant outcomes.

Indexed as

HSP70 Heat-Shock ProteinsHyperthermia, InducedLipid MetabolismLiverAdultFatty LiverFemaleHumansLiver TransplantationMaleMiddle AgedOrgan PreservationPerfusionHSP70 Heat-Shock Proteinshyperthermialipidslivermachine perfusionproteomics

Identifiers

PMID40346031
PMCPMC12064339

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.