Evidence map›Paper›PMID 40347370›Full record

ArticleNeurosurgical review2025

Serum peroxiredoxin 2 emerges as a predictive biomarker of poor neurological outcome and delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a prospective cohort study.

Zhengjie Fu, Junxia Dai, Qun Lin, Liangzhi Ye, Xiaoxiang Chen, Zhiwei Li, Chuan Lu, Maohua Chen, Huajun Ba, Jun Sun and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhengjie FuDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Junxia DaiDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Qun LinDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Liangzhi YeDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Xiaoxiang ChenDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Zhiwei LiDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Chuan LuDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Maohua ChenDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Huajun BaDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Jun SunDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China.
Jianyong CaiDepartment of Neurosurgery, The Dingli Clinical College of Wenzhou Medical University, The Wenzhou Central Hospital, 252 Bailidong Road, Wenzhou, 325000, China. caijy19761976@126.com.

Funding

Medical Health Science and Technology Project of Zhejiang Provincial Health Commission 2022KY1199Zhejiang Provincial Public Welfare Research Project LGD21H090005Zhejiang Provincial Public Welfare Research Project LGD22H090014
6 · The paper itself

Abstract

Peroxiredoxin 2 (Prdx2), an oxidative mediator, participates in acute brain injury. Here, serum Prdx2 levels were measured in order to assess its prognostic significance in aneurysmal subarachnoid hemorrhage (aSAH). In this prospective cohort study, serum Prdx2 levels were detected in 100 controls and 161 patients with aSAH. The modified Fisher scale (mFisher) and World Federation of Neurological Surgeons Scale (WFNS) were selected as two severity metrics. Post-aSAH 6-month Glasgow outcome scale (GOS) score of 1-3 was termed as poor prognosis. Poor prognosis and delayed cerebral ischemia (DCI) were chosen as two outcome variables of interest. Severity correlation and prognosis association with serum Prdx2 levels were investigated using multiple factorial approaches. Patients had markedly higher serum Prdx2 levels than controls. Serum Prdx2 levels, in independent correlation with WFNS scores and mFisher scores, were independently associated with DCI, poor prognosis, continuous GOS scores and ordinal GOS scores. Serum Prdx2 levels and two other independent predictors, that is WFNS scores and mFisher scores, were merged to form two models for predicting DCI and poor prognosis respectively. The two models were visually represented via the nomogram, and occupied satisfactory validity, stability and discrimination efficiency under decision curve, calibration curve and receiver operating characteristic curve. Serum Prdx2 levels of substantial promotion after aSAH are firmly linked to severity, DCI and bad 6-month prognosis of patients, strengthening serum Prdx2 as a useful prognostic biomarker of aSAH.

Indexed as

Brain IschemiaPeroxiredoxinsSubarachnoid HemorrhageAdultAgedBiomarkersCohort StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsPrognosisProspective StudiesBiomarkersPeroxiredoxinsPRDX2 protein, humanAneurysmBiomarkersCohort studyOutcomePeroxiredoxin 2Subarachnoid hemorrhage

Identifiers

PMID40347370

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.