Evidence map›Paper›PMID 40347408›Full record

ArticleInflammopharmacology2025

Exploring the potential of Moringa oleifera seed extract-loaded microemulsion hydrogel in the DNCB-induced atopic dermatitis model.

Prakrati Garg, Aaliya Ali, Sewa Singh, Kanika Thakur, Kaisar Raza, Bigul Yogeshver Bhardwaj, Saurabh Kulshrestha, Poonam Negi

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Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Prakrati GargSchool of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh, 173229, India.
Aaliya AliDepartment of Biotechnology, University Centre for Research and Development, Chandigarh University, Mohali, Punjab, 140413, India.
Sewa SinghMalkana Research Lab, Himachal Pradesh, Palampur, 176061, India.
Kanika ThakurSchool of Pharmaceutical Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh, 173229, India.
Kaisar RazaDepartment of Pharmacy, School of Chemical Sciences and Pharmacy, Central University of Rajasthan, Ajmer, India.
Bigul Yogeshver BhardwajSchool of Pharmaceutical Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh, 173229, India.
Saurabh KulshresthaSchool of Applied Sciences and Biotechnology, Shoolini University of Biotechnology and Management Sciences, Shoolini University, PO Box 9, Solan, Himachal Pradesh, 173229, India. saurabh_kul2000@yahoo.co.in.
Poonam NegiDepartment of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, 140401, India. poonamgarge@gmail.com.ORCID http://orcid.org/0000-0003-3722-991X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMoringa oleifera n-hexane (MO n-Hex) seed extract contains phytoconstituents such as behenic acid, quercetin, and kaempferol. These exhibit anti-inflammatory, antiallergic, and antioxidant properties and can alleviate atopic dermatitis (AD)-like symptoms. PURPOSE: This study aimed to develop and evaluate MO n-Hex seed extract-loaded microemulsion (ME) hydrogel to provide an effective, safe, non-steroidal, plant-based alternative to conventional therapies in the topical management of AD.

methodsOptimized o/w ME was developed by building pseudo-ternary phase diagrams. Ex vivo skin penetration was determined by employing CLSM analysis. Further, skin compatibility, histological analysis, and pharmacodynamics were carried out using a DNCB-induced AD model in BALB/c mice.

resultsThe best o/w ME demonstrated nearly spherical globules with size < 50 nm, zeta potential - 28.83 ± 0.492, and pH value 5.433 ± 0.047. The in vivo efficacy revealed significant improvements in AD-like symptoms, healed ear skin lesions, and lowered IgE levels and inflammatory cytokiness (IL-4, IL-5, and IFN-γ). Further, histological analysis confirmed the restoration of skin structure, supporting the formulation's potential in skin barrier repair.

conclusionsThe study demonstrated that the MO n-Hex seed extract-loaded MEs were suitable for topical use with improved penetration to deeper layers of skin while showing safety and better skin compliance. The formulated MEs effectively modulated immune responses and restored skin structure and barrier functioning.

Indexed as

Dermatitis, AtopicHydrogelsMoringa oleiferaPlant ExtractsSeedsAnimalsAnti-Inflammatory AgentsDinitrochlorobenzeneDisease Models, AnimalEmulsionsFemaleMiceMice, Inbred BALB CSkinAnti-Inflammatory AgentsDinitrochlorobenzeneEmulsionsHydrogelsPlant ExtractsBehenic acidCytokinesDrumstickEczemaHistologyPseudo-ternary phase diagram

Identifiers

PMID40347408

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.