Trial reportJournal of the National Cancer Institute2025
Reduced adipose tissue with limited loss of lean mass after weight loss: results from the Prostate Cancer Active Lifestyle Study.
Trial report in Journal of the National Cancer Institute, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Digital Nutritional Care in Oncology: Opportunities to Enhance Quality of Life and Support Patient-Centered Care.Cancers · 2026Review
- AI-Based Imaging Assessment of Body Composition in Oncology: A Step Toward Routine Clinical Practice Integration.Healthcare (Basel, Switzerland) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Adiposity reduction has cancer-specific and overall health benefits for patients with overweight or obesity. The indiscriminate loss of lean mass accompanying weight loss, however, remains a concern for older patients with cancer. Body composition was evaluated in the Prostate Cancer Active Lifestyle Study, a randomized controlled weight loss trial targeting caloric restriction and increased physical activity among patients with prostate cancer and overweight or obesity on active surveillance. Compared with control individuals, the intervention statistically significantly decreased total fat (‒3.4%, 95% CI = ‒5.3% to ‒1.5%), android fat (‒2.0%, 95% CI = ‒3.6% to ‒0.4%), and visceral adipose tissue mass (‒613 g, 95% CI = ‒894 to ‒331 g) (all 2-sided P < .001), with no difference in lean mass (P = .70) and a statistically significant increase in lean mass to fat ratio (0.40, 95% CI = 0.06 to 0.73; 2-sided P = .02). Weight loss interventions incorporating diet and physical activity among patients with prostate cancer and overweight or obesity can yield statistically significant reductions in adiposity while limiting lean mass loss.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.