Evidence map›Paper›PMID 40348201›Full record

ArticleNeurobiology of disease2025

Rodent and human seizures demonstrate a dynamic interplay with spreading depolarizations.

Jacob H Norby, Daniel Hummel, Noah Ricks, John Rolston, Shervin Rahimpour, Rhiannon Cowan, Juha Voipio, Andrew J Trevelyan, Elliot H Smith, R Ryley Parrish

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
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  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jacob H NorbyDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA; Neuroscience Center, Brigham Young University, Provo, UT, USA.
Daniel HummelDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA; Neuroscience Center, Brigham Young University, Provo, UT, USA.
Noah RicksDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA.
John RolstonHarvard Medical School, Boston, MA, USA.
Shervin RahimpourDepartment of Neurosurgery, University of Utah, Salt Lake City 84112, UT, USA.
Rhiannon CowanDepartment of Neurosurgery, University of Utah, Salt Lake City 84112, UT, USA.
Juha VoipioFaculty of Biological and Environmental Sciences, Molecular and Integrative Biosciences, University of Helsinki, Helsinki 00014, Finland.
Andrew J TrevelyanNewcastle University Biosciences Institute, Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK.
Elliot H SmithDepartment of Neurosurgery, University of Utah, Salt Lake City 84112, UT, USA. Electronic address: e.h.smith@utah.edu.
R Ryley ParrishDepartment of Cell Biology and Physiology, Brigham Young University, Provo, UT, USA; Neuroscience Center, Brigham Young University, Provo, UT, USA. Electronic address: ryley_parrish@byu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Seizure termination has been linked to spreading depolarizations (SDs) in experimental models of epilepsy, and SDs have been suggested to protect against seizures. However, the precise mechanisms of seizure-associated SDs remain unclear. Additionally, the co-occurrence of SDs with human seizures remains debated. In this study, we found that SDs are a prominent feature following ictal events in both human clinical recordings and in a rodent model of ictogenesis. Approximately one-third of rodent seizure-like events (SLEs) associated with SDs, while all human seizures analyzed associated with propagating infraslow shifts, indicative of SDs. In rodents, SDs clustered towards the end of ictal events, resulting in significantly shorter SLEs and delayed onset of subsequent SLEs. Interestingly, SLEs with SDs displayed significantly more low gamma activity during ictal events than SLEs that did not end in SDs. Furthermore, we found no significant correlation between [K

Indexed as

BrainCortical Spreading DepressionSeizuresAdultAnimalsDisease Models, AnimalElectroencephalographyFemaleHumansMaleMiddle AgedRatsYoung AdultEpilepsyIctal dischargeInfraslow oscillationsSpreading depression

Identifiers

PMID40348201
PMCPMC12086139

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.