Evidence map›Paper›PMID 40348383›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2025

Measuring biventricular function and left atrial volume in a single five-dimensional whole-heart cardiovascular magnetic resonance scan at 0.55T.

Xavier Sieber, Katherine Binzel, Juliet Varghese, Yingmin Liu, Jerome Yerly, Christopher W Roy, Panagiotis Antiochos, Milan Prsa, Ruud B van Heeswijk, Orlando P Simonetti and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Cardiac function assessment with deep-learning-based automatic segmentation of free-running four-dimensional whole-heart cardiovascular magnetic resonance.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xavier SieberDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Katherine BinzelDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Juliet VargheseDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA.
Yingmin LiuDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Jerome YerlyDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; CIBM Center for Biomedical Imaging, Lausanne, Switzerland.
Christopher W RoyDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Panagiotis AntiochosDepartment of Cardiology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Milan PrsaWoman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Ruud B van HeeswijkDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland.
Orlando P SimonettiDorothy M. Davis Heart and Lung Research Institute, The Ohio State University, Columbus, Ohio, USA; Department of Radiology, The Ohio State University, Columbus, Ohio, USA; Department of Internal Medicine, Division of Cardiovascular Medicine, The Ohio State University, Columbus, Ohio, USA.
Matthias StuberDepartment of Diagnostic and Interventional Radiology, Lausanne University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland; CIBM Center for Biomedical Imaging, Lausanne, Switzerland. Electronic address: mstuber.mri@gmail.com.

Funding

Development and validation of cardiovascular MRI techniques on a low-field, ultra-wide bore system to assess patients with severe obesityR01HL161618 · NHLBI · OHIO STATE UNIVERSITY · PI Orlando Paul Simonetti · 2022 to 2026
$2.9M
NHLBI NIH HHS R01 HL161618
6 · The paper itself

Abstract

backgroundCardiovascular magnetic resonance (CMR) has not seen widespread adoption beyond large urban academic centers. The reasons for this limited uptake include the cost, time-intensive nature, and special expertise of CMR. Self-navigated five-dimensional (5D), x-y-z-cardiac-respiratory, free-funning whole-heart CMR using self-navigation (5D CMR) implemented on a low-field clinical scanner may help bridge this gap for biventricular function assessment and left atrium volume index measurement.

methodsWhole-heart three-dimensional radial phyllotaxis balanced steady-state free precession data were collected in ten healthy adult subjects. Self-navigation was used to extract respiratory and cardiac motion signals and to generate motion-resolved 5D CMR datasets. The right- and left-ventricular ejection fraction (RVEF and LVEF), left atrial volume index, contrast ratio, sharpness, perceived image quality, and total scan durations were ascertained and compared to those obtained with the reference 2D cine images.

results5D CMR allowed for time-efficient and concordant measurements when compared to the 2D reference method. The 5D CMR images resulted in lower CR on 5D CMR images (3.3±2.9) than on 2D cines (4.7±1.2), and similarly lower perceived image quality (1.8±0.8 for 5D CMR and 3.6±0.9 for the 2D cines). However, the LVEF measurements were similar with no statistically significant differences (Mean: 58±5% for 5D CMR and 59±5% for 2D cine, p=0.49) and the LoA were low (-2.81% to 3.81%). For the RVEF, the measurements were also in good agreement when RVEF was measured on the axial views (60±3% for 5D CMR and 60±4% for 2D cine, p=0.85) and the LoA were also low (-2.87% to 3.07%).

conclusion5D CMR without the need for electrocardiogram, breath-holding, navigators, or complex scan planning enables a highly simplified and time-efficient assessment of biventricular cardiac function on a 0.55T clinical system in 7:50 min.

Indexed as

Atrial Function, LeftHeart AtriaImage Interpretation, Computer-AssistedImaging, Three-DimensionalMagnetic Resonance Imaging, CineStroke VolumeVentricular Function, LeftVentricular Function, RightAdultFemaleHealthy VolunteersHumansMaleMiddle AgedPredictive Value of TestsReproducibility of Results0.55T5DBiventricular functionFree-runningLow-fieldSelf-gated

Identifiers

PMID40348383
PMCPMC12166699

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.