Evidence map›Paper›PMID 40348419›Full record

ReviewThe Psychiatric clinics of North America2025

Genetics of Anorexia Nervosa: Translation to Future Personalized Therapies.

Jiayi Xu, Daria Igudesman, Laura M Huckins, Cynthia M Bulik

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Psychiatric clinics of North America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiayi XuDepartment of Psychiatry, Yale School of Medicine, 60 Temple Street, Suite 7A, New Haven, CT 06510, USA. Electronic address: jiayi.xu@yale.edu.
Daria IgudesmanAdventHealth Translational Research Institute, 301 E Princeton Street, Orlando, FL 32804, USA.
Laura M HuckinsDepartment of Psychiatry, Yale School of Medicine, 60 Temple Street, Suite 7A, New Haven, CT 06510, USA.
Cynthia M BulikDepartment of Psychiatry, University of North Carolina at Chapel Hill, CB #7160, 101 Manning Drive, Chapel Hill, NC 27599-7160, USA; Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Funding

Eating Disorders Genetics Initiative (EDGI)R01MH120170 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2019 to 2023
$7.2M
High-throughput in vivo and in vitro functional and multi-omics screens of neuropsychiatric and neurodevelopmental disorder risk genesRM1MH132648 · NIMH · YALE UNIVERSITY · PI Kristen Jennifer Brennand, Rong Fan · 2023 to 2026
$5.6M
1/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136149 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYNTHIA M BULIK, Laura Marianne Huckins · 2024 to 2026
$5.1M
Modeling the interaction of physiological and environmental stressors on common variants to psychiatric traitsR01ES033630 · NIEHS · YALE UNIVERSITY · PI Kristen Jennifer Brennand · 2022 to 2026
$4.6M
Cross-Population Working Group on Genes and Environment in Major Depression (POP-GEM): Advancing the Understating of Etiology through DiversityR01MH125938 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI Roseann Elizabeth Peterson · 2022 to 2026
$4.2M
Predicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · YALE UNIVERSITY · PI HUCKINS, LAURA MARIANNE · 2019 to 2023
$3.6M
1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5M
Predicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems ApproachR01MH119084 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, BUTNER, JONATHAN · 2019 to 2022
$2.8M
3/7 Psychiatric Genomics Consortium: Advancing Discovery and ImpactR01MH124839 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ANDREASSEN, OLE A, HUCKINS, LAURA MARIANNE · 2021 to 2025
$2.0M
Genetic Architecture of Avoidant/Restrictive Food Intake DisorderR56MH129437 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, MICALI, NADIA · 2022 to 2023
$1.5M
NIEHS NIH HHS R01 ES033630NIMH NIH HHS R01 MH118278NIMH NIH HHS R01 MH119084NIMH NIH HHS R01 MH120170NIMH NIH HHS R01 MH124839NIMH NIH HHS R01 MH124871NIMH NIH HHS R01 MH125938NIMH NIH HHS R01 MH136149NIMH NIH HHS R56 MH129437NIMH NIH HHS RM1 MH132648
6 · The paper itself

Abstract

Anorexia nervosa (AN) is a debilitating and often refractory eating disorder that is unique among psychiatric disorders insofar as nutrition is key to recovery. Treatment options and efficacy are limited with no approved medications for AN. Genetic studies are clarifying the etiology of AN, with the goal of eventually informing the development of innovative personalized pharmacologic, nutritional, microbial, and behavioral interventions. We present the current state of genome-wide and epigenome-wide association studies, gut microbiome research, and functional genomics investigations and discuss translating this knowledge into clinical practice.

Indexed as

Anorexia NervosaPrecision MedicineGastrointestinal MicrobiomeGenome-Wide Association StudyHumansAnorexia nervosaEpigeneticsGeneticsGut microbiomeGWASNutritional psychiatryRegistered dietitian

Identifiers

PMID40348419
PMCPMC13561541

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.