Evidence map›Paper›PMID 40348749›Full record

ArticleNature communications2025

Mapping the interaction surface between Ca

Francisco Castilla, Victor Lugo, Erick Miranda-Laferte, Nadine Jordan, Pitter F Huesgen, Beatrix Santiago-Schübel, Mercedes Alfonso-Prieto, Patricia Hidalgo

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francisco Castilla *Institute of Biological Information Processing (IBI-1)-Molecular and Cellular Physiology, Forschungszentrum Jülich, Jülich, Germany.
Victor Lugo *Institute of Biological Information Processing (IBI-1)-Molecular and Cellular Physiology, Forschungszentrum Jülich, Jülich, Germany.
Erick Miranda-LaferteInstitute of Biological Information Processing (IBI-1)-Molecular and Cellular Physiology, Forschungszentrum Jülich, Jülich, Germany.
Nadine JordanInstitute of Biological Information Processing (IBI-1)-Molecular and Cellular Physiology, Forschungszentrum Jülich, Jülich, Germany.
Pitter F HuesgenCentral Institute of Engineering, Electronics and Analytics (ZEA-3), Forschungszentrum Jülich, Jülich, Germany.ORCID http://orcid.org/0000-0002-0335-2242
Beatrix Santiago-SchübelCentral Institute of Engineering, Electronics and Analytics (ZEA-3), Forschungszentrum Jülich, Jülich, Germany. b.santiago-schuebel@fz-juelich.de.ORCID http://orcid.org/0000-0002-1762-9900
Mercedes Alfonso-PrietoInstitute of Neuroscience and Medicine (INM-9)-Computational Biomedicine, Forschungszentrum Jülich, Jülich, Germany. m.alfonso-prieto@fz-juelich.de.ORCID http://orcid.org/0000-0003-4509-4517
Patricia HidalgoInstitute of Biological Information Processing (IBI-1)-Molecular and Cellular Physiology, Forschungszentrum Jülich, Jülich, Germany. pa.hidalgo@fz-juelich.de.ORCID http://orcid.org/0000-0002-4162-6590

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Defective ion channel turnover and clearance of damaged proteins are associated with aging and neurodegeneration. The L-type Ca

Indexed as

ActinsCalcium Channels, L-TypeAnimalsCalciumCalcium SignalingCell MembraneHEK293 CellsHumansMiceMutationProtein BindingActinsCalciumCalcium Channels, L-Type

Identifiers

PMID40348749
PMCPMC12065904

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.