Evidence map›Paper›PMID 40348971›Full record

Trial reportBMC anesthesiology2025

The impact of hydromorphone combined with ropivacaine in serratus anterior plane block on postoperative pain in patients undergoing video-assisted thoracoscopic pulmonary lobectomy: a randomized, double-blind clinical trial.

Xuefeng Chen, Weifeng Zhang, Lin Wang, Weibing Wang, Yuhong Li

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xuefeng ChenDepartment of Anesthesiology, Shangyu People's Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, 312300, China.
Weifeng ZhangDepartment of Anesthesiology, Shangyu People's Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, 312300, China.
Lin WangDepartment of Anesthesiology, Shangyu People's Hospital of Shaoxing, Shaoxing University, Shaoxing, Zhejiang, 312300, China.
Weibing WangDepartment of Epidemiology, School of Public Health, Fudan University, Shanghai, 200032, China.
Yuhong LiDepartment of Anesthesiology, Shulan (Hangzhou) Hospital, Shulan International Medical College, Zhejiang Shuren University, Zhejiang, 312028, China. yuh_li@zju.edu.cn.

Funding

the Medical and Health Science and Technology Program of Zhejiang Provincial Health Commission 2022KY1319
6 · The paper itself

Abstract

backgroundThis study aimed to assess the effects of hydromorphone as an adjuvant to ropivacaine serratus anterior plane block (SAPB) on postoperative analgesia and inflammatory responses in patients undergoing video-assisted thoracoscopic surgery (VATS).

methodsThis was a prospective, randomized, double-blind clinical trial. A total of 120 lung cancer patients, aged 20-75 years, with an American Society of Anesthesiologists classification of I or II and a body mass index of 18-28 kg/m², were randomly assigned to three groups: ropivacaine combined with hydromorphone SAPB (HR group), ropivacaine SAPB (R group), and control (C group). Ultrasound-guided deep SAPB was used to inject medications. The main observed indicators were postoperative visual analog scale (VAS) pain scores, serum inflammatory markers (C-reactive protein (CRP), IL-6, TNF-α), intraoperative medication dosage, postoperative complication rates, and analgesic effects.

resultsPostoperative VAS pain scores were significantly reduced in the HR and R groups compared to the C group, especially at 6 h postoperatively. The median VAS score in the HR group was 2.00 (inter-quartile ratio (IQR): 2.00, 2.00), which was significantly lower than that of the C group's score of 3.00 (IQR: 3.00, 3.00; P < 0.001). The CRP levels at 24 and 48 h postoperatively in the HR group were 23.80 mg/L and 21.65 mg/L, respectively, significantly lower than the C group's levels of 56.65 mg/L and 82.75 mg/L, P < 0.001. The levels of IL-6 and TNF-α were also significantly lower in the HR group than in the C group. Intraoperative propofol and remifentanil dosages in the HR group were reduced to 5.22 mg/kg/h and 7.59 µg/kg/h, respectively, lower than the C group's dosages of 5.93 mg/kg/h and 5.74 µg/kg/h, P < 0.001. The incidence of postoperative nausea and vomiting in the HR group was 12.5%, which was lower than that in Group C (35.7%, P = 0.032).

conclusionRopivacaine adjuvant with hydromorphone in SAPB reducing postoperative pain and inflammatory in patients undergoing VATS, which contributed to rapid recovery. However, future studies should explore the long-term benefits and concenntration of hydromorphone of SAPB before it taken into clinical use.

trial registrationChinese Clinical Trial Register on August 19, 2021, NCT number ChiCTR2100053893.

Indexed as

Analgesics, OpioidAnesthetics, LocalHydromorphoneNerve BlockPneumonectomyPostoperative PainThoracic Surgery, Video-AssistedAdultAgedAmidesDouble-Blind MethodDrug Therapy, CombinationFemaleHumansLung NeoplasmsMaleAmidesAnalgesics, OpioidAnesthetics, LocalHydromorphoneRopivacaineHydromorphoneInflammatory responseLung cancerPostoperative analgesiaSerratus anterior plane blockVideo-assisted thoracoscopic surgery

Identifiers

PMID40348971
PMCPMC12065182

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.