Evidence map›Paper›PMID 40349073›Full record

ArticleActa neuropathologica communications2025

Partial normalization of hippocampal oscillatory activity during sleep in TgF344-AD rats coincides with increased cholinergic synapses at early-plaque stage of Alzheimer's disease.

Monica van den Berg, Loran Heymans, Daniëlle Toen, Mohit A Adhikari, Johan Van Audekerke, Marlies Verschuuren, Isabel Pintelon, Winnok H De Vos, Annemie Van der Linden, Marleen Verhoye and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Monica van den BergBio-Imaging Lab, University of Antwerp, Campus Drie Eiken - Building UC, Universiteitsplein 1, Wilrijk, 2610, Belgium. monica.vandenberg@uantwerpen.be.ORCID 0000-0003-1356-270X
Loran HeymansBio-Imaging Lab, University of Antwerp, Campus Drie Eiken - Building UC, Universiteitsplein 1, Wilrijk, 2610, Belgium.
Daniëlle ToenBio-Imaging Lab, University of Antwerp, Campus Drie Eiken - Building UC, Universiteitsplein 1, Wilrijk, 2610, Belgium.
Mohit A AdhikariBio-Imaging Lab, University of Antwerp, Campus Drie Eiken - Building UC, Universiteitsplein 1, Wilrijk, 2610, Belgium.
Johan Van AudekerkeBio-Imaging Lab, University of Antwerp, Campus Drie Eiken - Building UC, Universiteitsplein 1, Wilrijk, 2610, Belgium.
Marlies VerschuurenLaboratory of Cell Biology and Histology, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium.
Isabel PintelonLaboratory of Cell Biology and Histology, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium.
Winnok H De VosLaboratory of Cell Biology and Histology, University of Antwerp, Universiteitsplein 1, Wilrijk, 2610, Belgium.
Annemie Van der LindenBio-Imaging Lab, University of Antwerp, Campus Drie Eiken - Building UC, Universiteitsplein 1, Wilrijk, 2610, Belgium.
Marleen Verhoye *Bio-Imaging Lab, University of Antwerp, Campus Drie Eiken - Building UC, Universiteitsplein 1, Wilrijk, 2610, Belgium. marleen.verhoye@uantwerpen.be.
Georgios A Keliris *Bio-Imaging Lab, University of Antwerp, Campus Drie Eiken - Building UC, Universiteitsplein 1, Wilrijk, 2610, Belgium. georgios.keliris@outlook.com.

Funding

Internationale Stichting Alzheimer Onderzoek SAO-FRA-20180003Vlaamse Overheid FWO-G045420NVlaamse Overheid FWO-G048917N
6 · The paper itself

Abstract

Sleep alterations are known to occur in Alzheimer's disease (AD), before cognitive symptoms become apparent, and are thought to play an important role in the pathophysiology of AD. However, knowledge on the extent of macro- and microstructural changes of sleep during early, presymptomatic stages of AD is limited. We hypothesize that Aβ-induced perturbations of neuronal activity disrupt this oscillatory activity during sleep at pre-plaque stages of AD. In this study, we aimed to assess hippocampal oscillatory activity during sleep at pre- and early-plaque stages of AD, by performing 24-hour hippocampal electrophysiological measurements in TgF344-AD rats and wildtype littermates at pre- and early-plaque stages of AD. To provide a mechanistic understanding, histological analysis was performed to quantify GABA-ergic, glutamatergic and cholinergic synapses. We observed a differential impact of AD on hippocampal activity during rapid eye movement (REM) and non-REM (NREM) sleep, in the absence of robust changes in circadian rhythm. TgF344-AD rats demonstrated increased duration of sharp wave-ripples during NREM sleep, irrespective of age. Interestingly, a significantly decreased theta-gamma coupling was observed in TgF344-AD rats, prior to amyloid plaque deposition, which was partially restored at the early-plaque stage. The partial recovery of hippocampal activity during REM sleep coincided with an increased number of cholinergic synapses in the hippocampus during the early-plaque stage in TgF344-AD rats, suggestive of basal forebrain cholinergic compensation mechanisms. The results from this study reveal early changes in hippocampal activity prior to Aβ plaque deposition in AD. In addition, the current findings imply an important role of the cholinergic system to compensate for AD-related network alterations, thereby partially restoring sleep architecture and hippocampal activity.

Indexed as

Alzheimer DiseaseCholinergic NeuronsHippocampusPlaque, AmyloidSleepSynapsesAnimalsDisease Models, AnimalMaleRatsRats, Inbred F344Rats, TransgenicHippocampal local field potentialsNREM sleepPhase-amplitude couplingREM sleepSharp wave-ripplesTgF344-AD

Identifiers

PMID40349073
PMCPMC12065161

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.