Evidence map›Paper›PMID 40349270›Full record

ReviewDiscover oncology2025

The roles, signalling pathways and therapeutic implications of Apoc1 in cancer.

Hao-Han Guo, Qiang Guo, Qun-Xian Zhang, Dan Li, Yan Lv

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hao-Han GuoDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, China.
Qiang GuoDepartment of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan City, Hubei Province, China.
Qun-Xian ZhangDepartment of Cardiothoracic Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan City, Hubei Province, China.
Dan LiDepartment of Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan City, Hubei Province, China. 804180423@qq.com.
Yan LvDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital of Zunyi Medical University, Zunyi City, Guizhou Province, China. 568633195@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The apolipoprotein C (Apoc) family comprises a group of low-molecular-weight proteins that are essential for modulating lipoprotein metabolism, primarily influencing lipid transport and metabolic pathways. Apoc1, a member of the Apoc family, is consistently overexpressed across various cancers, significantly correlating with poor prognosis. The multifaceted role of Apoc1 includes promoting cancer progression by activating key signalling pathways such as epithelial-mesenchymal transition (EMT), mitogen-activated protein kinases (MAPK), STAT3 and WNT3 A. Additionally, Apoc1 contributes to the regulatory networks involving lncRNAs and miRNAs, thereby influencing cancer. This comprehensive review delineates Apoc1's mechanisms within malignant tumours and assesses its prognostic implications for patients with cancer. The aim is to shed light on potential novel therapeutic strategies in oncology, potentially revolutionising patient care and thereby enhancing patient survival rates and quality of life.

Indexed as

Apoc1CancerEpithelial–mesenchymal transitionMitogen-activated protein kinasesPrognosis

Identifiers

PMID40349270
PMCPMC12066387

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.