Evidence map›Paper›PMID 40349340›Full record

ArticleCell reports2025

Cancer-induced FOXP1 disrupts and reprograms skeletal-muscle circadian transcription in cachexia.

Jeremy B Ducharme, Daria Neyroud, Martin M Schonk, Miguel A Gutierrez-Monreal, Zhiguang Huo, Haley O Tucker, Karyn A Esser, Sarah M Judge, Andrew R Judge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Co-expression network analysis reveals repression ofbioRxiv : the preprint server for biology · 2026
    Article
  4. Cancer therapy and cachexia.The Journal of clinical investigation · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jeremy B DucharmeDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA; Myology Institute, University of Florida, Gainesville, FL, USA; University of Florida Health Cancer Center, Gainesville, FL, USA.
Daria NeyroudDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA; Myology Institute, University of Florida, Gainesville, FL, USA.
Martin M SchonkDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA; Myology Institute, University of Florida, Gainesville, FL, USA.
Miguel A Gutierrez-MonrealMyology Institute, University of Florida, Gainesville, FL, USA; Department of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Zhiguang HuoDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Haley O TuckerDepartment of Molecular Biosciences and the Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX, USA.
Karyn A EsserMyology Institute, University of Florida, Gainesville, FL, USA; Department of Physiology and Aging, University of Florida, Gainesville, FL, USA.
Sarah M JudgeDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA; Myology Institute, University of Florida, Gainesville, FL, USA; University of Florida Health Cancer Center, Gainesville, FL, USA. Electronic address: smsenf@phhp.ufl.edu.
Andrew R JudgeDepartment of Physical Therapy, University of Florida, Gainesville, FL, USA; Myology Institute, University of Florida, Gainesville, FL, USA; University of Florida Health Cancer Center, Gainesville, FL, USA. Electronic address: arjudge@phhp.ufl.edu.

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
University of Florida Health Cancer Center Support GrantP30CA247796 · NCI · UNIVERSITY OF FLORIDA · PI Alison Ivey · 2023 to 2026
$10.9M
FOXO signaling and skeletal muscle atrophyR01AR060209 · NIAMS · UNIVERSITY OF FLORIDA · PI JUDGE, ANDREW ROBERT · 2011 to 2021
$4.2M
MAR MEDIATED GENETIC SWITCH FOR IGH ENHANCER CONTROLR01CA031534 · NCI · UNIVERSITY OF TEXAS SW MED CTR/DALLAS · PI TUCKER, HALEY O · 1985 to 2012
$2.9M
Muscle clock and weakness: diversity supplementR01AR079220 · NIAMS · UNIVERSITY OF FLORIDA · PI ESSER, KARYN A · 2021 to 2025
$2.8M
The Complement System and Cancer CachexiaR01AR081648 · NIAMS · UNIVERSITY OF FLORIDA · PI Carl Atkinson, Andrew Robert Judge · 2022 to 2026
$2.3M
Matricellular proteins of the CNN family as regulators of tumor-induced cachexiaR01CA270025 · NCI · UNIVERSITY OF FLORIDA · PI Sarah M Judge · 2023 to 2026
$1.9M
Team-based Interdisciplinary Cancer Research Training ProgramT32CA257923 · NCI · UNIVERSITY OF FLORIDA · PI SIEMANN, DIETMAR W · 2021 to 2025
$1.2M
NCI NIH HHS P30 CA247796NCI NIH HHS R01 CA031534NCI NIH HHS R01 CA270025NCI NIH HHS T32 CA257923NIAMS NIH HHS R01 AR060209NIAMS NIH HHS R01 AR079220NIAMS NIH HHS R01 AR081648NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

Cancer cachexia is a debilitating metabolic disorder characterized by involuntary loss of body and muscle mass, leading to increased morbidity and mortality. We previously found that forkhead box P1 (FoxP1) upregulation in skeletal muscle causes muscle wasting and is required for muscle wasting in response to cancer. However, transcriptional networks targeted by FoxP1 in skeletal muscles undergoing cancer-induced wasting remain largely unknown. Here, we identify FoxP1 as a key disruptor of the skeletal-muscle clock in response to cancer that reprograms circadian patterns of gene expression at cachexia onset. Specifically, we show that cancer-induced FoxP1 rewires the skeletal-muscle circadian transcriptome toward pathways associated with muscle wasting and disrupts the temporal patterning of pathways governing glucose, lipid, and oxidative metabolism. These findings thus implicate cancer/disease-specific functions of FOXP1 in the disruption and reprograming of the skeletal-muscle circadian transcriptome, which may contribute to muscle wasting and the development of cachexia.

Indexed as

CachexiaCircadian RhythmForkhead Transcription FactorsMuscle, SkeletalNeoplasmsRepressor ProteinsTranscription, GeneticAnimalsHumansMaleMiceMice, Inbred C57BLTranscriptomeForkhead Transcription FactorsFoxp1 protein, mouseRepressor Proteinscancer cachexiaChIP-seqcircadian rhythmCP: Cancerinflammationmetabolismmuscle atrophymuscle clockpancreatic cancerRNA-seqskeletal muscle

Identifiers

PMID40349340
PMCPMC12166465

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.