ArticleCryobiology2025
Automated device for rapid sample cooling via controlled submersion.
Article in Cryobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Mechanistic insights into how water-network disorder determines the vitrification concentration in cryopreservation solutions.Cell reports. Physical science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
An automated device is described which enables programmable submersion in liquid nitrogen to enable rapid specimen cooling for vitrification applications. The device presented here is low-cost, portable, and compatible with a range of cryogenic containers. The device is capable of submerging samples at a range of speeds, enabling the user to optimize the cooling rates based on the thermal mass of the sample as well as the thermal properties of the container and biospecimen. The device consists of a stepper motor that drives a linear actuator, which enables the movement of a 3D-printed robotic arm in the vertical plane which is used to submerge the specimen rapidly into the cryogen. After development, the device was validated for its design parameters. The relative error in starting height and submersion distance was less than 1.5%, indicating a high degree of precision and consistency in positioning during operation. The resulting cooling rates showed no significant difference between manual and automated submersion, confirming the device's performance and reliability. The device performance was further assessed using a 0.25 mL insemination straw to evaluate its practical application. The cooling rate achieved was well within the range cited in previous reports as well as that predicted computationally, confirming the device's functionality. Importantly, this device can be constructed using commercially available materials at relatively low costs.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.