ArticleBMJ mental health2025
Identification of circadian-sensitive brain structure and its role in cognitive impairment and dementia.
Article in BMJ mental health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- A GABAergic neural circuit from the suprachiasmatic nucleus to DG drives cognitive impairment in migraine mice.The journal of headache and pain · 2026Article
- Reduced gray matter in the prefrontal cortex and hippocampus: a potential neuroanatomical feature of insomnia comorbid with anxiety.Frontiers in psychiatry · 2026Article
- Short-term continuous light exposure induces hippocampal rhythmic and functional alterations: a multi-timepoint metabolomics study.Frontiers in molecular biosciences · 2026Article
- Dysfunctional circadian-driven dynamics in gut microbiota and tumor microenvironment.Gut microbes · 2025Review
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCircadian disruption has been suggested to induce cognitive impairment and dementia. It remains unknown which brain structures are involved in the pathology.
objectiveTo investigate which specific brain structure alterations are associated with dementia and cognitive impairment induced by circadian disruption.
methodsCircadian disruption was represented by two accelerometer-derived circadian variables, composite phase deviations (CPD) and relative amplitude (RA), separately reflecting circadian disruption in timing and amplitude. The outcomes include brain structures (139 imaging-derived phenotypes), cognitive test performances (seven cognitive tests) and dementia (all-cause dementia, Alzheimer's disease, vascular dementia (AD/VD) and non-AD/VD dementia). Association analysis was used to explore the relationships between circadian disruption and brain structure alterations, cognitive test performances and dementia. Mediation analysis was conducted to investigate which brain structure alterations mediated the cognitive impairment and dementia caused by circadian disruption.
findingsA total of 88 461 participants (57% female, 62.0±7.8-year old) were included. CPD and RA correlated with substantially different brain structures. All CPD-related brain structures were located in the cerebrum, whereas most RA-related brain structures were located in the cerebellum. Furthermore, only the CPD-related brain structures, including the hippocampus and thalamus, exhibited significant mediation effects accounting for up to 8.6% of the risk for dementia and 13.5% of the risk for cognitive impairment.
conclusionsCircadian disruption is associated with brain structural alterations involving dementia and cognitive impairments. CLINICAL IMPLICATIONS: These results provide a novel insight into the mechanism underlying circadian disruption-induced neurological disorder and may propose potential preventive strategy.
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