Evidence map›Paper›PMID 40350326›Full record

Observational studyNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2025

Prolonged exposure to leisure screen time notably accelerates biological aging: Evidence from observational studies and genetic associations.

Jie Wen, Yuchen Wang, Xueyi Mao, Ruoyan Lei, Jinglin Zhou, Jingwei Zhang, Hongwei Liu, Quan Cheng

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jie WenDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; Hypothalamic Pituitary Research Centre, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Yuchen WangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; Hypothalamic Pituitary Research Centre, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Xueyi MaoXiangya School of Medicine, Central South University, Changsha, China.
Ruoyan LeiXiangya School of Public Health, Central South University, Changsha, China.
Jinglin ZhouDepartment of Immunology and Inflammation, Cancer Cell Protein Metabolism, The Hugh and Josseline Langmuir Centre for Myeloma Research, Centre for Haematology, Imperial College London, London, United Kingdom.
Jingwei ZhangDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; Hypothalamic Pituitary Research Centre, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: xyyyzjw@csu.edu.cn.
Hongwei LiuDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; Hypothalamic Pituitary Research Centre, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: hongweiliu0315@csu.edu.cn.
Quan ChengDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: chengquan@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LST is steadily increasing and is associated with various health issues. However, its impact on aging remains unclear. A total of 7212 participants from NHANES 1999-2002 were included. LTL, ALM, and FI were selected as aging phenotypes. Observational association between LST and aging traits was analyzed using linear regression models. MR analyses based on 112 genetic variants were performed to test the causal estimates from LST on aging. TWAS and PPI analyses were conducted to investigate underlying biological mechanisms. After adjusting for physical activity, per 1 ​h increase in LST, participants had a shorter LTL (β ​= ​-1.39, 95 ​% CI: -2.47 to -0.30), a lower ALM (β ​= ​-1.09, 95 ​% CI: -1.39 to -0.70), and an increased FI (β ​= ​8.22, 95 ​% CI: 4.29 to 12.30). Likewise, TSMR analyses indicated that genetically increased LST was significantly associated with shorter LTL (β ​= ​-2.63, 95 ​% CI: -4.86 to -0.35), lower ALM (β ​= ​-6.56, 95 ​% CI: -9.43 to -3.60), and increased FI (β ​= ​20.16, 95 ​% CI: 15.73 to 24.77). The trend remained robust after tests for pleiotropy and heterogeneity, consistent with the results of MVMR. 4 hub genes and 15 co-localized genes are identified, respectively, from PPI networks and TWAS. Pathways related to immune reactions, oxidative stress, and protein metabolism were significantly enriched. This study revealed that increased LST is significantly associated with adverse aging phenotypes. Reducing LST may help alleviate the burden of aging.

Indexed as

AgingLeisure ActivitiesScreen TimeAdultAgedExerciseFemaleGenetic Association StudiesHumansMaleMiddle AgedNutrition SurveysAgingLeisure screen timeMendelian randomizationNHANESTWAS

Identifiers

PMID40350326
PMCPMC12418421

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.